Effects of intracameral injection of viscoelastic solutions on corneal endothelium in dogs

Paul A. Gerding Jr. From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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Susan A. McLaughlin From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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Alan H. Brightman From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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Diane Essex-Sorlie From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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Ronald A. Laing From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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Kiminori Hirokawa From the Department of Veterinary Clinical Medicine (Gerding, McLaughlin, Brightman), Department of Veterinary Pathobiology (Essex-Sorlie), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801, and Boston University School of Medicine (Laing, Hirokawa), Boston, MA 02118.

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SUMMARY

Contact in vivo wide-field specular microscopy was performed on right eyes of 20 healthy dogs after sodium hyaluronate (1%, n = 5), sodium chondroitin sulfate (4%) and sodium hyaluronate (3%, n = 5), hydroxypropyl methylcellulose (2%, n = 5), or balanced salt solution (control, n = 5) was injected into the anterior chamber. Using computerized morphometric analysis and pachymetry, changes in endothelial cell density, cell morphologic features, and corneal thickness from baseline values were evaluated at postinjection hour (pih) 72 and pih 168. Changes were not seen in endothelial cell density or cell morphologic features in any treated eye. The mean corneal thickness of all treated eyes at pih 72 increased 6%, significantly greater than that of the nontreated eyes (P = 0.03). Mean corneal thickness of treated and nontreated eyes was similar at baseline and pih 168 in all treatment groups.

SUMMARY

Contact in vivo wide-field specular microscopy was performed on right eyes of 20 healthy dogs after sodium hyaluronate (1%, n = 5), sodium chondroitin sulfate (4%) and sodium hyaluronate (3%, n = 5), hydroxypropyl methylcellulose (2%, n = 5), or balanced salt solution (control, n = 5) was injected into the anterior chamber. Using computerized morphometric analysis and pachymetry, changes in endothelial cell density, cell morphologic features, and corneal thickness from baseline values were evaluated at postinjection hour (pih) 72 and pih 168. Changes were not seen in endothelial cell density or cell morphologic features in any treated eye. The mean corneal thickness of all treated eyes at pih 72 increased 6%, significantly greater than that of the nontreated eyes (P = 0.03). Mean corneal thickness of treated and nontreated eyes was similar at baseline and pih 168 in all treatment groups.

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