Reference intervals for feline cerebrospinal fluid: Biochemical and serologic variables, IgG concentration, and electrophoretic fractionation

Jacqueline S. Rand From the Departments of Clinical Studies (Rand, Parent) Pathology (Jacobs) and Microbiology and Immunology (Johnson), Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1, Canada.

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 BVSc, DVSc
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Joane Parent From the Departments of Clinical Studies (Rand, Parent) Pathology (Jacobs) and Microbiology and Immunology (Johnson), Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1, Canada.

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 DVM, MSc
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Robert Jacobs From the Departments of Clinical Studies (Rand, Parent) Pathology (Jacobs) and Microbiology and Immunology (Johnson), Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1, Canada.

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 DVM, PhD
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Roger Johnson From the Departments of Clinical Studies (Rand, Parent) Pathology (Jacobs) and Microbiology and Immunology (Johnson), Ontario Veterinary College, University of Guelph, Guelph, Ontario, NIG 2W1, Canada.

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 MVSc, PhD

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SUMMARY

Reference intervals are reported for feline csf biochemical and serologic variables, IgG concentration, and electrophoretic fractionation, derived from 58 clinically normal adult cats that did not have histologic lesions of the cns. There was no apparent effect of age on any variable. The csf total protein concentration was significantly (P = 0.012) greater in males than in females, but all other variables were unaffected by gender. The only variable that had a statistically significant correlation with its corresponding blood concentration was IgG. Blood contamination of thecsf affected the following csf variables: total protein concentration, activities of lactate dehydrogenase and creatine kinase, IgG ratio, and γ-globulin percentage. The reference intervals proposed for feline csf were derived from 33 cats with csf rbc count < 31 cells/μl. Reference limits for csf with 31 to 1,700 rbc/μl also are reported.

SUMMARY

Reference intervals are reported for feline csf biochemical and serologic variables, IgG concentration, and electrophoretic fractionation, derived from 58 clinically normal adult cats that did not have histologic lesions of the cns. There was no apparent effect of age on any variable. The csf total protein concentration was significantly (P = 0.012) greater in males than in females, but all other variables were unaffected by gender. The only variable that had a statistically significant correlation with its corresponding blood concentration was IgG. Blood contamination of thecsf affected the following csf variables: total protein concentration, activities of lactate dehydrogenase and creatine kinase, IgG ratio, and γ-globulin percentage. The reference intervals proposed for feline csf were derived from 33 cats with csf rbc count < 31 cells/μl. Reference limits for csf with 31 to 1,700 rbc/μl also are reported.

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