Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection

Louis J. Lafrado From the Department of Veterinary Pathobiology (Lafrado, Mathes, Zack, Olsen), College of Veterinary Medicine, and The Comprehensive Cancer Center (Olsen), The Ohio State University, Columbus, OH 43210.

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Lawrence E. Mathes From the Department of Veterinary Pathobiology (Lafrado, Mathes, Zack, Olsen), College of Veterinary Medicine, and The Comprehensive Cancer Center (Olsen), The Ohio State University, Columbus, OH 43210.

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Philip M. Zack From the Department of Veterinary Pathobiology (Lafrado, Mathes, Zack, Olsen), College of Veterinary Medicine, and The Comprehensive Cancer Center (Olsen), The Ohio State University, Columbus, OH 43210.

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Richard G. Olsen From the Department of Veterinary Pathobiology (Lafrado, Mathes, Zack, Olsen), College of Veterinary Medicine, and The Comprehensive Cancer Center (Olsen), The Ohio State University, Columbus, OH 43210.

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SUMMARY

Biological effects of staphylococcal protein A (spa) immunotherapy were studied in 5 viremic and 6 nonviremic cats with induced FeLV infection and in 6 control cats. The spa therapy neither reversed FeLV viremia nor resulted in consistent improvement in humoral immune responses to FeLV antigens. However, spa immunotherapy induced a proliferative response in bone marrow granulocytic lineage, possibly resulting in expression of FeLV-free mature neutrophils in the blood. Seemingly, viral burden and chemiluminescent responses were reversed in viremic cats during spa immunotherapy.

SUMMARY

Biological effects of staphylococcal protein A (spa) immunotherapy were studied in 5 viremic and 6 nonviremic cats with induced FeLV infection and in 6 control cats. The spa therapy neither reversed FeLV viremia nor resulted in consistent improvement in humoral immune responses to FeLV antigens. However, spa immunotherapy induced a proliferative response in bone marrow granulocytic lineage, possibly resulting in expression of FeLV-free mature neutrophils in the blood. Seemingly, viral burden and chemiluminescent responses were reversed in viremic cats during spa immunotherapy.

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