Pharmacokinetics of etomidate in cats
Search for other papers by E. M. Wertz in
Current site
Google Scholar
PubMed
Search for other papers by G. J. Benson in
Current site
Google Scholar
PubMed
Search for other papers by J. C. Thurmon in
Current site
Google Scholar
PubMed
Search for other papers by W. J. Tranquilli in
Current site
Google Scholar
PubMed
Search for other papers by L. E. Davis in
Current site
Google Scholar
PubMed
Search for other papers by G. D. Koritz in
Current site
Google Scholar
PubMed
SUMMARY
Pharmacokinetic variables of etomidate were determined after iv administration of etomidate (3.0 mg/kg of body weight). Blood samples were collected for 6 hours. Disposition of this carboxylated imidazole best conformed to a 2- (n = 2) and a 3- compartment (n = 4) open pharmacokinetic model. The pharmacokinetic values were calculated for the overall best-fitted model, characterized as a mixed 2- and 3-compartmental model. The first and most rapid distribution half-life was 0.05 hour and a second distribution half-life was 0.35 hour. Elimination half-life was 2.89 hours, apparent volume of distribution was 11.87 ± 4.64 L/kg, apparent volume of distribution at steady state was 4.88 ± 2.25 L/kg, apparent volume of the central compartment was 1.17 ± 0.70 L/kg, and total clearance was 2.47 ± 0.78 L/kg/h.
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 7247 | 7111 | 21 |
| PDF Downloads | 100 | 51 | 2 |
