Pharmacokinetics of etomidate in cats

E. M. Wertz From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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G. J. Benson From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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J. C. Thurmon From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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W. J. Tranquilli From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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L. E. Davis From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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G. D. Koritz From the Departments of Veterinary Clinical Medicine (Wertz, Benson, Thurmon, Tranquilli) and Biosciences (Davis, Koritz), College of Veterinary Medicine, University of Illinois, Urbana, IL 61801.

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SUMMARY

Pharmacokinetic variables of etomidate were determined after iv administration of etomidate (3.0 mg/kg of body weight). Blood samples were collected for 6 hours. Disposition of this carboxylated imidazole best conformed to a 2- (n = 2) and a 3- compartment (n = 4) open pharmacokinetic model. The pharmacokinetic values were calculated for the overall best-fitted model, characterized as a mixed 2- and 3-compartmental model. The first and most rapid distribution half-life was 0.05 hour and a second distribution half-life was 0.35 hour. Elimination half-life was 2.89 hours, apparent volume of distribution was 11.87 ± 4.64 L/kg, apparent volume of distribution at steady state was 4.88 ± 2.25 L/kg, apparent volume of the central compartment was 1.17 ± 0.70 L/kg, and total clearance was 2.47 ± 0.78 L/kg/h.

SUMMARY

Pharmacokinetic variables of etomidate were determined after iv administration of etomidate (3.0 mg/kg of body weight). Blood samples were collected for 6 hours. Disposition of this carboxylated imidazole best conformed to a 2- (n = 2) and a 3- compartment (n = 4) open pharmacokinetic model. The pharmacokinetic values were calculated for the overall best-fitted model, characterized as a mixed 2- and 3-compartmental model. The first and most rapid distribution half-life was 0.05 hour and a second distribution half-life was 0.35 hour. Elimination half-life was 2.89 hours, apparent volume of distribution was 11.87 ± 4.64 L/kg, apparent volume of distribution at steady state was 4.88 ± 2.25 L/kg, apparent volume of the central compartment was 1.17 ± 0.70 L/kg, and total clearance was 2.47 ± 0.78 L/kg/h.

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