Humoral immune response to immediate-early protein of pseudorabies virus in swine with induced or naturally acquired infection
Andrew K. Cheung
 PhD
Andrew K. Cheung
From the National Animal Disease Center, Agricultural Research Service, USDA, PO Box 70, Ames, IA 50010.
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SUMMARY
Pseudorabies virus (prv) immediate-early (ie) protein is a nonglycosylated polypeptide localized in the nuclei of infected cells. The ie protein is a regulatory protein that is only synthesized during viral replication and is presented to the immune system of prv-infected swine. Antibodies to the ie protein were demonstrated in swine with induced or naturally acquired infection. However, antiserum raised against purified ie protein could not neutralize prv in vitro.
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