Evaluation of drug-induced prostatic involution in dogs by transabdominal B-mode ultrasonography

R. E. Cartee From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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P. F. Rumph From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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D. C. Kenter From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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J. C. Cooney From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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D. Frank From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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J. Haught From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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P. Leong From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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M. Humphries From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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P. Amaratunga From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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N. Zampaglioni From the Department of Anatomy and Histology, College of Veterinary Mediae, 109 Greene Hall, Auburn University, AL 36849-5518.

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SUMMARY

The relative antiandrogen-induced prostate involution activity of the newly synthesized hydroxyflutamide prodrug was compared with that of flutamide in 25 Beagles. Secondary antiandrogen activity of both drugs on the testes and mammary tissue was investigated. Daily oral administration of both compounds at 2 dosages (ie, 2.5 and 5.0 mg/kg of body weight) during a 7-week period was monitored by transabdominal ultrasonography of the prostate twice a week. Cross-sectional area estimates of the prostate gland calculated from oblique dorsoventral, and transverse sonographic measurements were diminished significantly in some of the treated dogs as early as day 14 of drug administration. All treated dogs had significant differences in reduction by day 47. Involution was related directly to dose (P < 0.05), but no difference was observed between test compounds. Differences in secondary antiandrogen activity were not remarkable. Flutamide was not found to have any activity advantage in vivo over hydroxyflutamide. It was concluded that ultrasonography can be a highly effective means of monitoring prostate size, and of monitoring drug-induced involution over time.

SUMMARY

The relative antiandrogen-induced prostate involution activity of the newly synthesized hydroxyflutamide prodrug was compared with that of flutamide in 25 Beagles. Secondary antiandrogen activity of both drugs on the testes and mammary tissue was investigated. Daily oral administration of both compounds at 2 dosages (ie, 2.5 and 5.0 mg/kg of body weight) during a 7-week period was monitored by transabdominal ultrasonography of the prostate twice a week. Cross-sectional area estimates of the prostate gland calculated from oblique dorsoventral, and transverse sonographic measurements were diminished significantly in some of the treated dogs as early as day 14 of drug administration. All treated dogs had significant differences in reduction by day 47. Involution was related directly to dose (P < 0.05), but no difference was observed between test compounds. Differences in secondary antiandrogen activity were not remarkable. Flutamide was not found to have any activity advantage in vivo over hydroxyflutamide. It was concluded that ultrasonography can be a highly effective means of monitoring prostate size, and of monitoring drug-induced involution over time.

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