Modified transvenous endomyocardial biopsy technique in dogs

Bruce W. Keene From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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Mark E. Kittleson From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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Clarke E. Atkins From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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John E. Rush From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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Steven W. Eicker From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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Paul Pion From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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Vera Regitz From the Department of Medical Sciences (Keene, Rush, Atkins), and Surgical Sciences (Eicker), University of Wisconsin-Madison, School of Veterinary Medicine, The Department of Medicine (Kittleson, Pion), University of California-Davis, College of Veterinary Medicine, and The Berlin Herzcentrum (Regitz), Berlin, Federal Republic of Germany.

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SUMMARY

A technique for transvenous endomyocardial biopsy of the right ventricle was developed and evaluated for safety and efficacy in healthy dogs and dogs with dilated cardiomyopathy positioned in lateral recumbency. This technique allowed acquisition of multiple biopsy specimens from the right ventricle of each of 22 hemodynamically normal dogs and 40 of 42 dogs with congestive heart failure. In 2 dogs with dilated cardiomyopathy, transvenous access to the right ventricle could not be achieved, but left ventricular biopsy was performed without complication. Complications were infrequent, and dogs recovered to at least their baseline status within 48 hours. Evaluation of the efficacy and complication rate of the procedure with each of the 2 biopsy instruments currently available identified no differences between them.

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