Pharmacokinetics of pipemidic acid in chickens after single intravenous and oral dosings

A. Anadón From the Institute of Pharmacology and Toxicology, CSIC, Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.

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M. R. Martinez-Larrañaga From the Institute of Pharmacology and Toxicology, CSIC, Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.

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M. J. Diaz From the Institute of Pharmacology and Toxicology, CSIC, Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.

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C. Velez From the Institute of Pharmacology and Toxicology, CSIC, Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.

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P. Bringas From the Institute of Pharmacology and Toxicology, CSIC, Department of Pharmacology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain.

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SUMMARY

The pharmacokinetics of pipemidic acid after 2 single doses were studied in broiler chickens. Chickens were given single iv and oral doses of 10 and 30 mg of pipemidic acid/ kg of body weight. Blood samples were collected over 8 hours after each dose administration. High-pressure liquid chromatography with uv detection was used to determine concentrations in plasma of pipemidic acid. The plasma concentration-time curves after iv administration followed 2-compartment characteristics, rapid initial distribution phase, and a terminal elimination phase. The pharmacokinetic variables differed significantly between single doses of 10 and 30 mg of pipemidic acid/kg. Mean disposition variables were a half-life at α phase of 0.06 hours or 0.33 hours, a half-life at β phase of 1.18 hours or 1.72 hours, a volume of distribution in the central compartment of 0.12 L/kg or 0.31 L/kg, a volume of distribution during the elimination β phase of 1.64 L/kg or 1.05 L/kg, and a total plasma clearance of 0.97 L/h·kg or 0.41 L/h-kg, for the 10 or 30 mg/kg dose, respectively. After oral administration, the pipemidic acid plasma profile could be adequately described by a 1-compartment model. After the single oral doses of 10 and 30 mg of pipemidic acid/kg, pipemidic acid was absorbed rapidly (time to maximal concentration of 0.31 hours or 0.71 hours) and eliminated with a mean half-life of 0.86 hours or 0.61 hours, respectively. The bioavailability was 39% at 10 mg of pipemidic acid/kg and 61% at 30 mg of pipemidic acid/kg.

SUMMARY

The pharmacokinetics of pipemidic acid after 2 single doses were studied in broiler chickens. Chickens were given single iv and oral doses of 10 and 30 mg of pipemidic acid/ kg of body weight. Blood samples were collected over 8 hours after each dose administration. High-pressure liquid chromatography with uv detection was used to determine concentrations in plasma of pipemidic acid. The plasma concentration-time curves after iv administration followed 2-compartment characteristics, rapid initial distribution phase, and a terminal elimination phase. The pharmacokinetic variables differed significantly between single doses of 10 and 30 mg of pipemidic acid/kg. Mean disposition variables were a half-life at α phase of 0.06 hours or 0.33 hours, a half-life at β phase of 1.18 hours or 1.72 hours, a volume of distribution in the central compartment of 0.12 L/kg or 0.31 L/kg, a volume of distribution during the elimination β phase of 1.64 L/kg or 1.05 L/kg, and a total plasma clearance of 0.97 L/h·kg or 0.41 L/h-kg, for the 10 or 30 mg/kg dose, respectively. After oral administration, the pipemidic acid plasma profile could be adequately described by a 1-compartment model. After the single oral doses of 10 and 30 mg of pipemidic acid/kg, pipemidic acid was absorbed rapidly (time to maximal concentration of 0.31 hours or 0.71 hours) and eliminated with a mean half-life of 0.86 hours or 0.61 hours, respectively. The bioavailability was 39% at 10 mg of pipemidic acid/kg and 61% at 30 mg of pipemidic acid/kg.

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