Clinicopathologic and pathologic findings of herpesvirus-induced urinary tract infection in conventionally reared cats

John M. Kruger From the Departments of Small Animal Clinical Sciences (Kruger, Osborne), veterinary Diagnostic Investigation (Goyal, Pomeroy), and Veterinary Pathobiology (O'Brien), College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Search for other papers by John M. Kruger in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Carl A. Osborne From the Departments of Small Animal Clinical Sciences (Kruger, Osborne), veterinary Diagnostic Investigation (Goyal, Pomeroy), and Veterinary Pathobiology (O'Brien), College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Search for other papers by Carl A. Osborne in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Sagar M. Goyal From the Departments of Small Animal Clinical Sciences (Kruger, Osborne), veterinary Diagnostic Investigation (Goyal, Pomeroy), and Veterinary Pathobiology (O'Brien), College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Search for other papers by Sagar M. Goyal in
Current site
Google Scholar
PubMed
Close
 BVSc, PhD
,
Kem A. Pomeroy From the Departments of Small Animal Clinical Sciences (Kruger, Osborne), veterinary Diagnostic Investigation (Goyal, Pomeroy), and Veterinary Pathobiology (O'Brien), College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Search for other papers by Kem A. Pomeroy in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Timothy D. O’Brien From the Departments of Small Animal Clinical Sciences (Kruger, Osborne), veterinary Diagnostic Investigation (Goyal, Pomeroy), and Veterinary Pathobiology (O'Brien), College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108.

Search for other papers by Timothy D. O’Brien in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

SUMMARY

Clinicopathologic manifestations of induced infection of the feline lower urinary tract with bovid herpesvirus-4 (bhv-4, strain FCAHV) were characterized in 6 conventionally reared adult cats (2 sexually intact males, 2 castrated males, and 2 females). Two additional control cats were exposed with noninfected cell culture control inoculum. Clinical and radiographic signs of lower urinary tract disease were not observed in exposed or control cats. Microscopic hematuria was detected in urine samples collected by cystocentesis from 4 of 6 exposed cats and 1 of 2 control cats. Results of culture of urine for bacteria, maycoplasmas, ureaplasmas, and viruses were consistently negative. Low titer of serum bhv-4 (strain FCAHV)- neutralizing antibodies was detected in 4 of 6 exposed cats, but not in controls.

Gross abnormalities of the urinary tract were not observed in any cat. Light microscopic examination of serial sections of the lower urinary tract revealed mild focal lymphoid cystitis in 2 of 6 exposed cats, one of which also had increased amounts of connective tissue and proliferation of blood vessels in the urinary bladder lamina propria. Ninety days after initial exposure, bhv-4 (strain FCAHV) was reisolated from explanted urinary bladder tissues of 5 of 6 exposed cats. Virus was not isolated from tissues of control cats.

It was concluded that bhv-4 (strain FCAHV) establishes persistent urinary tract infection in conventionally reared adult male and female cats. However, persistent bhv-4 infection in cats may remain clinically inapparent.

SUMMARY

Clinicopathologic manifestations of induced infection of the feline lower urinary tract with bovid herpesvirus-4 (bhv-4, strain FCAHV) were characterized in 6 conventionally reared adult cats (2 sexually intact males, 2 castrated males, and 2 females). Two additional control cats were exposed with noninfected cell culture control inoculum. Clinical and radiographic signs of lower urinary tract disease were not observed in exposed or control cats. Microscopic hematuria was detected in urine samples collected by cystocentesis from 4 of 6 exposed cats and 1 of 2 control cats. Results of culture of urine for bacteria, maycoplasmas, ureaplasmas, and viruses were consistently negative. Low titer of serum bhv-4 (strain FCAHV)- neutralizing antibodies was detected in 4 of 6 exposed cats, but not in controls.

Gross abnormalities of the urinary tract were not observed in any cat. Light microscopic examination of serial sections of the lower urinary tract revealed mild focal lymphoid cystitis in 2 of 6 exposed cats, one of which also had increased amounts of connective tissue and proliferation of blood vessels in the urinary bladder lamina propria. Ninety days after initial exposure, bhv-4 (strain FCAHV) was reisolated from explanted urinary bladder tissues of 5 of 6 exposed cats. Virus was not isolated from tissues of control cats.

It was concluded that bhv-4 (strain FCAHV) establishes persistent urinary tract infection in conventionally reared adult male and female cats. However, persistent bhv-4 infection in cats may remain clinically inapparent.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 88 88 53
PDF Downloads 28 28 4
Advertisement