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application during laparoscopy. 1 , 3 Certain oral antifungals, such as itraconazole, have been reported to be poorly tolerated in certain common psittacine species, such as African grey parrots. 1 , 4 Voriconazole is currently considered the most effective

Open access
in Journal of the American Veterinary Medical Association

, posaconazole is considerably more expensive than fluconazole or itraconazole and there are no published reports of its use in cats with histoplasmosis. 15 Voriconazole is a second-generation triazole synthesized from fluconazole. The pharmacokinetics of IV

Full access
in Journal of the American Veterinary Medical Association

associated with captivity, preexisting comorbidities, trauma, and prolonged medical treatment predisposes these birds to aspergillosis. Voriconazole is the drug of choice for the treatment of aspergillosis in humans 8 and has shown potential usefulness in

Open access
in American Journal of Veterinary Research

imidazoles (miconazole and ketoconazole) or triazoles (itraconazole, fluconazole, and voriconazole) depending on the number of nitrogen atoms on the azole ring. 17 The azole agents inhibit ergosterol synthesis in fungal cell membranes by interfering with the

Full access
in American Journal of Veterinary Research

-term treatment. Voriconazole is a second-generation triazole antifungal drug registered for use in the treatment of humans with invasive aspergillosis and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. a Similar to other

Full access
in American Journal of Veterinary Research

activity, except for Fusarium spp, but does not penetrate the eyes of healthy horses after IV or oral administration. 19 Ketoconazole is poorly absorbed after oral administration, and miconazole is toxic when administered parenterally. 18 Voriconazole

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in American Journal of Veterinary Research

alternative is voriconazole, a synthetic triazole antifungal agent available in IV and oral formulations. 2,3 Voriconazole inhibits fungal 14-alpha-sterol-demethylase (a CYP-dependent enzyme) and disrupts the fungal cell membrane and halts fungal growth. In

Full access
in American Journal of Veterinary Research

successful, and mortality rates among infected birds remain high. 2,3 Voriconazole is a second-generation triazole antifungal drug that is derived from fluconazole and is available in preparations for IV and oral administration. 4 Like other triazoles

Full access
in American Journal of Veterinary Research

Voriconazole, a second-generation triazole that is available in IV and oral formulations, provides a new and improved treatment option for fungal infections. 1 Voriconazole is modified from fluconazole by substitution of a fluoropyrimidine ring

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in American Journal of Veterinary Research

itraconazole is most commonly used as a prophylactic or for long-term treatment. 4,10 Voriconazole is a second-generation triazole drug with broad-spectrum antifungal activity developed for use in immunocompromised humans. 11–13 It can be administered PO or

Full access
in American Journal of Veterinary Research