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Authors
Courtney L. Sexton , Dog Aging Project Consortium
and

care and EOL decisions, in order for dogs to serve as an effective translational model for human disease outcomes, biomarkers, and aging, this knowledge gap regarding the average dog lifespan—not only life expectancies for specific breeds or categories

Open access
in Journal of the American Veterinary Medical Association

H ealth care has improved as the world’s population ages, but the incidence of chronic, progressive neurodegenerative disease has increased. A critical challenge to dementia drug development has been the absence of translational models to drive

Open access
in American Journal of Veterinary Research

Abstract

OBJECTIVE

The objective of this study was to characterize extracellular vesicles (EVs) in plasma and synovial fluid obtained from horses with and without naturally occurring post-traumatic osteoarthritis (PTOA).

ANIMALS

EVs were isolated from plasma and synovial fluid from horses with (n = 6) and without (n = 6) PTOA.

METHODS

Plasma and synovial fluid EVs were characterized with respect to quantity, size, and surface markers. Small RNA sequencing was performed, and differentially expressed microRNAs (miRNAs) underwent bioinformatic analysis to identify putative targets and to explore potential associations with specific biological processes.

RESULTS

Plasma and synovial fluid samples from horses with PTOA had a significantly higher proportion of exosomes and a lower proportion of microvesicles compared to horses without PTOA. Small RNA sequencing revealed several differentially expressed miRNAs, including miR-144, miR-219-3p, and miR-199a-3l in plasma and miR-199a-3p, miR-214, and miR-9094 in synovial fluid EVs. Bioinformatics analysis of the differentially expressed miRNAs highlighted their potential role in fibrosis, differentiation of chondrocytes, apoptosis, and inflammation pathways in PTOA.

CLINICAL RELEVANCE

We have identified dynamic molecular changes in the small noncoding signatures of plasma and synovial fluid EVs in horses with naturally occurring PTOA. These findings could serve to identify promising biomarkers in the pathogenesis of PTOA, to facilitate the development of targeted therapies, and to aid in establishing appropriate translational models of PTOA.

Open access
in Journal of the American Veterinary Medical Association

variety of conditions. Dr. Vanessa Hale, assistant professor in the Department of Veterinary Preventive Medicine and associate director of the CoMS, studies the gut and urine microbiome of wildlife and domestic animals as translational models for

Open access
in American Journal of Veterinary Research

of equal clinical importance in other companion animal species and some authors have suggested that the cat may be as apt a translational model of aging in humans as the dog, 13 this manuscript focuses on canine aging both in the interest of

Full access
in Journal of the American Veterinary Medical Association

-L , et al. Canine epilepsy as a translational model? Epilepsia 2013 ; 54 : 571 – 579 . 10.1111/epi.12138

Full access
in Journal of the American Veterinary Medical Association

by pressure on the spinal cord . Pathol Vet . 1969 ; 6 : 355 – 368 . 20. Alisauskaite N , Spitzbarth I , Baumgärtner W , et al . Chronic post-traumatic intramedullary lesions in dogs, a translational model . PLoS One . 2017 ; 12 : e

Open access
in Journal of the American Veterinary Medical Association

Services , 2017 . 29. Dickinson PJ LeCouteur RA Higgins RJ , et al. Canine spontaneous glioma: a translational model system for convection-enhanced delivery . Neuro Oncol 2010 ; 12 : 928 – 940 . 10.1093/neuonc/noq046 30. Potschka H Fischer

Full access
in American Journal of Veterinary Research

used as a translational model for human patients with this condition. Furthermore, preferential binding of autoantibodies to the GFAP-α in dogs with MUO may be indicative of a more pathogenic autoantibody pheno-type, and that characteristic might be

Full access
in American Journal of Veterinary Research