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commercially available and provide a rapid single-point result with good sensitivity/specificity. Symmetric dimethylarginine (SDMA) is a sensitive early marker of acute and chronic renal disease in dogs and cats. 8 – 10 Since 2019, SDMA has been included in

Open access
in American Journal of Veterinary Research

mammalian biochemical parameters such as blood urea nitrogen (BUN) and creatinine (CREAT) do not increase until at least 75% of the kidney mass is diseased or damaged. 1 , 3 Symmetric dimethylarginine increases earlier in states of kidney compromise with

Open access
in American Journal of Veterinary Research

has been historically confirmed by high serum concentrations of urea nitrogen, creatinine, or phosphorus or high urine protein-to-creatinine ratio (UPC), alone or in combination, in concert with findings on urinalysis. 4 Symmetric dimethylarginine

Full access
in Journal of the American Veterinary Medical Association

serum creatinine concentration are elevated. 10,13 A newer method of assessing renal function is measuring serum SDMA concentration. Symmetric dimethylarginine is a small-molecule byproduct of cellular catabolism recently identified as a novel kidney

Full access
in American Journal of Veterinary Research

renal function. Moreover, some extrarenal factors, such as diet, muscle mass, and breed, are known to influence Cr. 5 , 6 Symmetric dimethylarginine (SDMA) is another kidney biomarker that also accurately reflects GFR, as it is eliminated almost

Full access
in American Journal of Veterinary Research

clindamycin for suspected otitis media–otitis interna had resulted in a minimal response. A routine CBC and serum biochemical analyses were performed and revealed a slightly high symmetric dimethylarginine concentration (18 µg/dL; reference range, 0 to 14 µg

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in Journal of the American Veterinary Medical Association

macrocytic normochromic anemia (Hct, 7.2%) and mildly elevated direct (0.19 mg/dL; rr, 0 to 0.08 mg/dl) and total bilirubin (0.94 mg/dL; rr, 0 to 0.85 mg/dl). The symmetric dimethylarginine concentration was above the upper reference limit for this biomarker

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in Journal of the American Veterinary Medical Association

lesion. Blood biochemistry revealed a mild increase in symmetric dimethylarginine (SDMA) concentration without associated azotemia ( Table 1 ) . Urinalysis of a sample collected via cystocentesis revealed specific gravity of 1.020, urine protein

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in Journal of the American Veterinary Medical Association

results from samples collected with operant conditioning, further tests (eg, assessments of electrolytes and urea waste product in urine 12 and symmetric dimethylarginine in blood q ) may follow to thoroughly evaluate an animal's renal condition

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in Journal of the American Veterinary Medical Association

radiography of the dog's neck and thorax were performed. Serum biochemical analyses included assessment of concentrations of glucose, total protein, albumin, urea, creatinine, sodium, potassium, symmetric dimethylarginine, thyroxine, triiodothyronine, and free

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in Journal of the American Veterinary Medical Association