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in Journal of the American Veterinary Medical Association

March 2020 with the Surgical Oncology Service at VCA West Coast Specialty and Emergency Animal Hospital were reviewed. Dogs were included if they were ≥ 8 years of age at presentation, underwent a major surgical procedure under general anesthesia, and

Open access
in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE

To compare the influence of fluid on carboplatin elution, and assess the feasibility of ultrafiltration (UF) probe sampling

SAMPLE

20 samples of 5 mg carboplatin in 1.0 mL 30% poloxamer 407 eluting in Dulbecco’s phosphate-buffered saline (DPBS) or canine plasma and 6 samples of UF probe sampling in 0.01 mg/mL carboplatin in DPBS or plasma.

METHODS

Carboplatin-gel specimens in dialysis tubing (12- to 14-kDa pores) were placed in 100 mL of DPBS or canine plasma (37 °C and 600 rpm stirring) in a nonlidded and lidded experiment. Samples were collected in decreasing frequency for 96 hours. The 0.01-mg/mL carboplatin solutions in DPBS and plasma were sampled 6 times by UF probe (30-kDa pores) or direct aspiration. Platinum was measured using inductively coupled plasma mass spectrometry.

RESULTS

High fluid evaporation was noted in the nonlidded but not the lidded experiment. A burst release was seen in plasma (first 2 hours) and DPBS (first 5 hours) with the highest hourly increase in the first hour in both DPBS (6,040 ppb/h) and plasma (2,612 ppb/h), with no further increase after the first 22 hours. Platinum content in the specimens was higher at 96 hours than the surrounding fluid. Higher platinum concentrations were measured by both direct and UF probe sampling in DPBS than in plasma.

CLINICAL RELEVANCE

Platinum concentrations measured in DPBS were higher than in plasma, but elution patterns were similar. Ultrafiltration probes can be used to sample platinum in vitro and could be used in vivo to measure local unbound Pt tissue concentrations in local chemotherapy delivery.

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in American Journal of Veterinary Research

—The study proposal was approved by the Veterinary Society of Surgical Oncology Research Committee. Participating members of the Veterinary Society of Surgical Oncology were asked to search their medical record databases for dogs that weighed ≤ 15 kg in

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in Journal of the American Veterinary Medical Association

of dogs receiving various systemic adjuvant therapies. Materials and Methods Case accrual was solicited from Veterinary Society of Surgical Oncology members via email. b Inclusion criteria for the study were that dogs had histologically

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in Journal of the American Veterinary Medical Association

was approved by the research committee of the Veterinary Society of Surgical Oncology. Participating members of the Veterinary Society of Surgical Oncology were asked to search their medical record databases for cats with a histopathologic diagnosis of

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in Journal of the American Veterinary Medical Association

Charitable Trust validates that commitment. The Laiks gift will support collaborative research with the UF Health Cancer Center to elevate future discoveries, precision medicine, immunotherapy, and genome mapping. UFVH medical, radiation and surgical

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in Journal of the American Veterinary Medical Association

Surgical Oncology in 2009, 1 the pulmonary metastatic rate at the time of diagnosis was 28%. The dogs in this study that were treated with amputation alone had a mean survival time (MST) of 979 days, with a significant association being identified between

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in Journal of the American Veterinary Medical Association

(BWJ, GT, and MG). All authors are academic board-certified surgeons with additional training in surgical oncology. A consensus was then reached where elements were only included in the final template if they were considered essential information such

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in Journal of the American Veterinary Medical Association

BD , Davidson M . Eyelids, eye, and orbit . In: Kudnig ST , Seguin B , eds. Veterinary Surgical Oncology . Wiley-Blackwell ; 2012 : 383 – 404 . 3. Dubielzig RR . Tumors of the eye . In: Meuten DJ , ed. Tumors in Domestic Animals

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in Journal of the American Veterinary Medical Association