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feeding and atherosclerosis in experimental induction of the lesions in Quaker parrots. 6 , 7 The use of statin drugs is considered a mainstay of treatment for human hyperlipidemia and atherosclerosis. Atorvastatin administration in humans (maximum

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in American Journal of Veterinary Research

coadministration of prednisolone. Statins block the mevalonate pathway by hindering HMG-CoA reductase, which results in inhibition of cholesterol synthesis. As intracellular concentrations of cholesterol decrease, the low-density lipoprotein receptor is induced

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in Journal of the American Veterinary Medical Association

ischemia resulting from a stroke. Treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (ie, statins), such as simvastatin, has provided protection for human patients at risk for major vascular events. 1 There has been increasing

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in American Journal of Veterinary Research

urolith removal in dogs undergoing a cystotomy. See PAGE 763 Prednisolone and rosuvastatin for treatment of a pyogranuloma in a dog Statins are widely used in people for treatment of arteriosclerotic disease, but they also appear to represent

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in Journal of the American Veterinary Medical Association

Existing medications with known safety profiles in dogs may also affect MMPs and TIMPs in eyes with cPACG. For example, statins appear to blunt ECM modifications, inhibit TIMP-2, and modulate MMPs. 132 , 133 , 134 Although there has been some disagreement

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in American Journal of Veterinary Research

might have been a potential cause of the dyslipidemia in this dog. Human patients with FH are often managed medically with high dosages of statins. 13 Similarly, in the dog described in the present report, treatment was initiated with atorvastatin

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in Journal of the American Veterinary Medical Association

increase dietary α-linolenic acid and frequent monitoring of the patient's plasma cholesterol (and triglyceride) concentrations are vitally important. The use of cholesterol-lowering statin drugs appears to be clinically useful in avian patients. Other

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in Journal of the American Veterinary Medical Association

play in hepatic drug uptake, research has focused on identifying variants responsible for drug toxicosis or impaired uptake. 21 Variants within SLCO1B genes are associated with methotrexate clearance, statin-induced myopathy, and docetaxel

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in American Journal of Veterinary Research

Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment . Circulation 2003 ; 108 : 1567 – 1574 . 10.1161/01.CIR.0000091084.46500.BB 7. Arbustini E

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in American Journal of Veterinary Research

-dependent effects of statins . Arterioscler Thromh Vasc Biol 2003 ; 23 : 729 – 736 . 10.1161/01.ATV.0000063385.12476.A7 9 Preli RB Klein KP Herrington DM . Vascular effects of dietary L-arginine supplementation . Atherosclerosis 2002 ; 162 : 1

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in American Journal of Veterinary Research