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-out period and after completion of the study. This protocol was approved by the University of California-Davis Institutional Animal Care and Use Committee. IV regional limb perfusion In February 2023, horses received IVRLP with 2 g amikacin sulfate

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in American Journal of Veterinary Research

High vancomycin concentrations in regional synovial joints were described following IVRLP, 1 which could be applied clinically. Intravenous regional limb perfusion and IORLP provide high regional antimicrobial concentrations while maintaining low

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in American Journal of Veterinary Research

traumatic fractures. Regional limb perfusion is a well-established method for delivering antimicrobials at concentrations greater than the minimum inhibitory concentration for many common bacterial pathogens into the synovium and osseous and soft tissue

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in American Journal of Veterinary Research

Systemic and locoregional antimicrobials are often administered in combination for the treatment of orthopedic infections in horses. Regional limb perfusion with antimicrobials has become a common practice for treatment of infections in the distal

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in Journal of the American Veterinary Medical Association

Introduction Intravenous regional limb perfusion (IVRLP) is a common procedure in equine practice used to deliver high concentrations of an antimicrobial to infected regions in the distal limb. 1 – 3 This procedure consists of placement of a

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in American Journal of Veterinary Research

Intravenous regional limb perfusion is commonly used to treat horses with infections of the distal portion of the limb because the technique allows for accumulation of high antimicrobial concentrations within synovial structures, soft tissues, and

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in American Journal of Veterinary Research

. Regional limb perfusion provides high antimicrobial concentrations in the region of interest and greatly contributes to the elimination of the infection. 1,2 It involves the administration of a drug solution into the vasculature of a selected portion of

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in Journal of the American Veterinary Medical Association

Intravenous regional limb perfusion involves injection of a drug, usually an antimicrobial, into a portion of a limb isolated by a tourniquet to increase the concentration of drug locally. This technique results in decreased systemic adverse and

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in American Journal of Veterinary Research

), antimicrobial administration by regional limb perfusion is simple and allows therapeutic drug concentrations to be achieved locally with minimal risk for adverse systemic effects. 4 , 5 , 6 , 7 Administration of a drug by regional limb perfusion requires use

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in American Journal of Veterinary Research

Traumatic wounds in the limbs of horses are common and frequently involve synovial structures that can affect an animal's athletic career and even be life-threatening. 1–3 Regional limb perfusion with antimicrobials is a simple procedure that

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in American Journal of Veterinary Research