In countries where healthy female dogs (bitches) are not commonly spayed, pyometra has been diagnosed in up to 20% of sexually intact bitches before the age of 10. 1 Clinical signs may include dehydration, anemia, polydipsia, polyuria, anorexia
adhesions that was obstructive and precluded cervical patency. Pyometra secondary to transluminal cervical adhesions was diagnosed.
The purulent material was removed from the uterus over a period of days in an effort to reduce potential contamination
Pyometra is a common disease of sexually intact female dogs 1 , 2 and has been studied extensively as a model for sepsis and systemic inflammation. 3 – 7 Ovariohysterectomy (OHE) is well established as the recommended treatment for all cases of
Pyometra, infection of the uterus, can be a life-threatening condition for female cats (queens). 1 Prior research on pyometra has primarily focused on its occurrence in bitches, with few studies documenting the prevalence, characteristics, and
progesterone, while removing the uterus to prevent pregnancy and uterine disease such as pyometra. Currently, no evidence has been presented in regard to its efficacy in sterilization or development of stump pyometra or other sex hormone–related disorders, and
range, > 5 to 8 ng/mL) and 30.42 pg/mL (reference range, < 10 pg/mL), respectively. On the basis of these findings, the diagnosis was amended to type II vaginal fold prolapse with pyometra during diestrus.
Because the cyst in the right ovary might have
Pyometra is diagnosed in up to 20% 1 of sexually intact female dogs (bitches) before the age of 10 and in approximately 2% 2 of sexually intact female cats (queens) by the age of 13. Pyometra can be life-threatening and lead to severe
of the large distended, gas-filled structures were emphysematous pyometra, gastric distension-volvulus (GDV), or severe mechanical ileus. The smaller gas-filled structure was most likely a part of the emphysematous pyometra or mechanical ileus
Objective—To determine vasopressin (VP) secretory
capacity during osmotic stimulation and the response
to desmopressin treatment in dogs with pyometra
and control dogs.
Animals—6 dogs with pyometra before and after
ovariohysterectomy and 6 control dogs.
Procedure—Urine osmolality (Uosm) was measured
during 12 hours. Values measured on the first day
defined the basal Uosm pattern. On the second day,
dogs were given desmopressin to induce a desmopressin-stimulated Uosm pattern. On day 3, the VP
response to osmotic stimulation was examined.
Results—Median Uosm on day 1 was 340 mOsm/kg
(range, 104 to 1,273 mOsm/kg) and 807 mOsm/kg
(range, 362 to 1,688 mOsm/kg) in dogs with pyometra
before and after surgery, respectively, and 1,511
mOsm/kg (range, 830 to 1,674 mOsm/kg) in control
dogs. Median Uosm during desmopressin treatment
was 431 mOsm/kg (range, 168 to 1,491 mOsm/kg)
and 1,051 mOsm/kg (range, 489 to 1,051 mOsm/kg) in
dogs with pyometra before and after surgery, respectively,
and 1,563 mOsm/kg (range, 1,390 to 2,351) in
control dogs. In dogs with pyometra, threshold for VP
secretion was lower before surgery (median, 340
mOsm/kg; range, 331 to 366 mOsm/kg) than after
surgery (median, 358 mOsm/kg; range, 343 to 439
mOsm/kg) or in control dogs (median, 347 mOsm/kg;
range, 334 to 360 mOsm/kg). Highest maximum plasma
VP values were found in dogs with pyometra.
Conclusions and Clinical Relevance—Dogs with
pyometra had increased urine concentration in
response to desmopressin but not to the degree of
control dogs, whereas VP secretory ability was not
reduced. (Am J Vet Res 2004;65:404–408)
through May 2002, those with a presumptive diagnosis of pyometra for which treatment included ovariohysterectomy were entered in the study after informed owner consent was obtained. The presumptive diagnosis was made on the basis of signalment, history