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. ABBREVIATIONS 7-AAD 7-Aminoactinomycin D COX Cyclooxygenase DMSO Dimethyl sulfoxide ETE Eicosatetranone FBS Fetal bovine serum LTB 4 Leukotriene B 4 MTT 4,5-Dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide PGE 2 Prostaglandin E 2 SCC
approved for dogs. 6 – 10 It belongs in the piprant class of drugs that preserves the functions associated with COX enzymes pathways by directly binding to the prostaglandin E 2 receptor 4 (EP4), blocking the sensitization of sensory neurons and
a decrease in the production of prostanoids. In the kidneys, prostaglandins have a role in regulation of GFR, renin release, and sodium excretion. 6 Prostaglandins are synthesized by both COX-1 and COX-2 in healthy kidneys; however, when angiotensin
Summary
Dogs were treated with flunixin meglumine, a cyclooxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.
administration of TDFM decreases synthesis of PGE 2 , 5 which suggests that, as expected of an NSAID, TDFM inhibits production of prostaglandins through the arachidonic acid pathway. The TDFM is effectively absorbed through the skin of cattle 6 and alleviates
triphosphate U46619 9,11-dideoxy-9α,11α-methanoepoxy-prostaglandin F 2α A3P5PS Adenosine 3′-phosphate 5′-phosphosulfate a. Collagen Reagent “Horm,” Nycomed, Munich, Germany. b. A gift from Dr. R. G. Humphries, AstraZeneca R&D, Loughborough
of gestation was numerically but not significantly lower than that for the control ewes in the present study. Infection with BVDV can lead to both oophoritis and fetal death with subsequent release of prostaglandin F 2α from the endometrium, and
-inflam-matory steroid drugs on pain coping behaviours in a model of articular pain in the domestic fowl . Res Vet Sci 2001 ; 71 : 161 – 166 . 10.1053/rvsc.2001.0510 26. Anhut H Brune K Frölich JC , et al . Prostaglandin D2 is the prevailing
to thromboxane β 2 and the production of prostaglandins, which are potent mediators of inflammation. Cyclooxygenases are expressed in the CNS of vertebrates, and their relative expression varies depending on the species. 5 A broad tissue
R , et al. A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin E 2 levels in calves undergoing dehorning . Res Vet Sci 2013 ; 95 : 204 – 211 . 10.1016/j.rvsc.2013.01.018 18. Glynn HD