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inhibition of platelet function, which can be achieved by antagonism of specific platelet cell surface receptors, or interference with intracellular signaling pathways. Although the former provides high specificity, inhibition of platelet signal transduction

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in American Journal of Veterinary Research

Introduction Regenerative medicine represents a broad field of therapies aimed at healing or replacing damaged tissues or organs. Platelet-rich plasma (PRP) is a biological therapy within the regenerative medicine field; it is believed to

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in Journal of the American Veterinary Medical Association

Platelets are anucleate, discoid-shaped, cytoplasmic fragments that play an essential role in primary hemostasis, the initiation of a platelet plug, and the preservation of vascular integrity. Alterations in platelet number as well as platelet

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in American Journal of Veterinary Research

incoming inflammatory cells and fibroblasts as well as the presentation of growth factors to endothelial cells and fibroblasts. Platelet α granules contain a wide variety of growth factors and matrix proteins, which participate in all phases of wound

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in American Journal of Veterinary Research

A role for platelets as inflammatory cells is being increasingly recognized in multiple diseases of humans. 1 Thus, it has been suggested that pathologic platelet activation may contribute to atherosclerosis; ischemic heart disease; diabetes

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in American Journal of Veterinary Research

clinical signs, physical examination findings, and diagnostic test results. A diagnosis is often made after a thromboembolic episode has occurred. Coagulation is propagated and amplified on the platelet surface with expression of platelet

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in American Journal of Veterinary Research

comparison of platelet variables in EDTA- and citrate-anticoagulated blood in dogs has revealed that platelet counts are lower and MPV higher in 3.2% citrate samples than in EDTA samples, presumably because of increased platelet activation and aggregation in

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in American Journal of Veterinary Research

molecules. 20 – 22 Coated platelets are a subpopulation of platelets that are formed ex vivo after dual stimulation with thrombin and a glycoprotein (GP) VI agonist, such as convulxin. 23 , 24 Their surface is coated with procoagulant glycoproteins and

Open access
in American Journal of Veterinary Research

A vital function of platelets is to adhere to a site of vascular injury where collagen and other extracellular matrix proteins, including tissue factor, are exposed to flowing blood. The platelets provide a cellular surface for localized thrombin

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in American Journal of Veterinary Research

In addition to activation of secondary hemostasis and fibrinolysis, there is evidence of exercise-induced platelet activation in healthy athletes as reflected by unique platelet morphology indices determined by use of a laser-based hematology analyzer

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in American Journal of Veterinary Research