Search Results
agglomeration of widened but incomplete sulci that extends toward the right lateral ventricle (B). Orthogonal thoracic radiographs and cisternal CSF analysis were unremarkable. Sympathomimetic pharmacological testing with ocular application of 1
well as pharmacologic testing. 10 , 11 , 13 Commonly reported clinical signs and general physical examination findings associated with canine dysautonomia (CD) include lethargy, anorexia, weight loss, vomiting or regurgitation, diarrhea, tenesmus
Abstract
Objective—To determine signalment, history, clinical findings, results of autonomic function testing and other antemortem diagnostic tests, and pathologic findings in dogs with dysautonomia.
Design—Retrospective study.
Animals—65 dogs with dysautonomia.
Procedure—Case records of 68 dogs with a diagnosis of dysautonomia were reviewed; inclusion criteria included histologic confirmation of dysautonomia or clinical signs and results of pharmacologic testing consistent with dysautonomia.
Results—65 dogs fulfilled all criteria for dysautonomia. Dogs from rural environments were overrepresented, and cases of dysautonomia were reported for every month, although the highest number of cases was reported in February and March. Vomiting was the most common clinical sign, followed by diarrhea, signs of anorexia and depression, weight loss, and dysuria. The most common physical examination finding was decreased or absent anal tone, followed by absent pupillary light reflexes and elevated nictitating membrane. Results of pharmacologic te sting were consistent with dysautonomia, although no single test was 100% sensitive. Histologic lesions consistent with dysautonomia were found in the autonomic ganglia, brainstem nuclei, and ventral horns of the spinal cord.
Conclusions and Clinical Relevance—Dysautonomia is an endemic disease in Kansas, and a high index of suspicion of the disease can be made by combining clinical signs, physical examination findings, and results of pharmacologic testing. (J Am Vet Med Assoc 2002;220:633–639)
postganglionic or preganglionic sympathetic neurons with pharmacological testing. The application of 0.1-10% phenylephrine will resolve the symptoms of a postganglionic (third order) lesion due to complete denervation hypersensitivity at the postsynaptic membrane
electrophysiologic and pharmacological testing. 3 Administration of a single dose of neostigmine methylsulfate can be used to help strengthen a presumptive diagnosis of MG, but a negative response does not preclude this diagnosis. 3,10 Electrophysiologic evidence
pharmacological testing, such as the atropine response test, pilocarpine response test, and ID histamine test, along with results of tear production testing. 2,11,12 A definitive diagnosis requires histologic examination of autonomic ganglia and identification of
additional 0.55 mL of blood was collected from each flamingo prior to drug administration for preparation of blank plasma samples for pharmacological testing. During the study, all 16 flamingos were housed together in a holding room measuring 4.3 × 3.0 × 2
syndrome). The superficial corneal ulceration persisted in the left eye. The presence of permanent posterior synechiae, which had not resolved with topical administration of atropine, precluded localization of sympathetic denervation with pharmacologic
of enrofloxacin was widely accepted after pharmacologic testing revealed that such use achieved higher peak plasma drug concentrations, increased bactericidal efficacy, decreased risk of bacterial resistance, and provided increased ease of
