Search Results

You are looking at 1 - 10 of 28 items for :

  • "ovalbumin" x
  • Refine by Access: All Content x
Clear All

Research depicted that galangin alleviates ovalbumin (OVA)-induced airway inflammation by regulating the nuclear factor-κB (NF-κB) pathway, reducing total cell and eosinophil counts, lowering IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid, and

Open access
in American Journal of Veterinary Research

clearance of inhaled antigens. 7 Clearance of an inhaled prototype allergen (ovalbumin) in calves was prolonged because of infection with BRSV. 7 The link between RSV infection early in life and allergic sensitization has been substantiated in previous

Full access
in American Journal of Veterinary Research

Summary

The lungs of sensitized horses were exposed to aerosolized ovalbumin. Some horses (n = 4) were given ovalbumin in 1 lung only, whereas in others (n = 7), ovalbumin or vehicle were inoculated in the cranial, ventral, and caudal regions of the caudal lung lobe. Horses were exercised 5 hours after ovalbumin exposure. Immediately before exercise, endoscopy failed to reveal any abnormality. After exercise, endoscopic examination of horses subjected to unilateral ovalbumin exposure revealed extensive blood in airways leading to the exposed lung in all horses. Blood was not observed in the airways leading to the control lung. Mean (± sem) minimum volume of the exposed and control lungs was 9.5 ± 1.5 and 5.5 ± 1.6 L, respectively; this difference was statistically significant (P< 0.05). Bronchoscopy of horses subjected to regional ovalbumin or vehicle exposure and exercise revealed a small amount of blood-tinged fluid in the bronchi serving the regions of the lung inoculated with ovalbumin. Minimum volumes of such regions were not significantly different from one another. However, their minimum volume was significantly (P<0.05) larger than that of vehicle-inoculated regions. Gross and histologic examination confirmed inflammation and hemorrhage in the ovalbumin-exposed, but not the control lungs or lung regions. Thus, exercise can cause blood from an injured region of lung to appear in the larger airways. Regional differences in lung structure and function do not influence the appearance of blood in the airways.

Free access
in American Journal of Veterinary Research

triamine pentacetate OA Ovalbumin 99m Tc-OA 99m Technetium-labeled ovalbumin a. 99m Tc-DTPA, Amersham Health, Sacramento, Calif. b. Ovalbumin fraction V, Sigma Chemical Co, St Louis, Mo. c. Technicare Omega 500, QRS Systems, Cleveland, Ohio

Full access
in American Journal of Veterinary Research

Summary

The usefulness of tidal breathing flow-volume loops (tbfvl) to evaluate pulmonary function was investigated in 6 Standardbreds during treadmill exercise. Tidal breathing flow-volume loops are a graphic representation of airflow rate vs tidal volume for each individual breath. These tbfvl were obtained from horses exercising at speeds corresponding to 75 and 100% of maximum heart rate. Measurements were recorded in each horse before and after ovalbumin-induced allergic lung disease. Moderate obstructive lung disease, characterized by a significant increase in pulmonary resistance, was observed while the horses were at rest. We found that in horses with airway obstruction exercising at 75 or 100% of maximum heart rate, the quantitative indices describing tbfvl shape and size were not markedly different from those in clinically normal horses exercising at similar speeds.

Free access
in American Journal of Veterinary Research

SUMMARY

Lambs were inoculated during either fetal or early neonatal life with antigens of Haemonchus contortus (HcAg) third-stage larvae, or ovalbumin (ova), or were left untreated. By the time lambs were 4 weeks old, blood lymphocytes from all of them responded to HcAg. This was evident in all lambs, regardless of the previous inoculation regimen, although higher response was seen in HcAg-inoculated lambs, compared with naive lambs. Only lambs inoculated with ova had ova-specific lymphocyte activity. In HcAg-naive lambs, the maximal HcAg lymphocyte response was observed between the ages of 5 and 25 weeks, with gradual decrease thereafter. In vitro detection of HcAg-reactive lymphocytes was affected by antigen concentration and presence of plasma. Plasma inhibited HcAg-reactive lymphocytes from all lambs at high in vitro antigen concentration and completely abrogated the response in H contortus antigen-naive lambs.

Free access
in American Journal of Veterinary Research

the cytoplasm in H&E-stained sections. Because these granules were strongly positive with periodic acid–Schiff staining and negative with mucicarmine staining, they were interpreted as ovalbumin granules. The pancreas was surrounded by thick

Open access
in Journal of the American Veterinary Medical Association

were haphazardly arranged and lined by single to sometimes several layers of large, neoplastic epithelial cells. Cells contained abundant, brightly eosinophilic, cytoplasmic granules consistent with ovalbumin and had round to irregularly round to oval

Full access
in Journal of the American Veterinary Medical Association

approximately 2-fold in first-generation airways. 25 In rats with induced bronchitis, MUC5AC mRNA expression was increased 3-fold. 32 In a study 26 of ovalbumin-sensitized guinea pigs, MUC5AC mRNA expression was found to increase by 150% (mean value

Full access
in American Journal of Veterinary Research

S neurona vaccine results in specific antibody within the CSF, presumably because of transfer of antibody across the blood-brain barrier. 38 Similarly, antigen-specific antibody was detected in the CSF of horses after IM administration of ovalbumin

Full access
in American Journal of Veterinary Research