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an increased risk for sustaining bone damage, with the sternal carina (keel) and tibiotarsal bones being common sites. 3 Fractures and bone margin deviations secondary to low bone mineral density (BMD; osteoporosis) can cause pain, stress, increased
Horses that have a BFS (including SAO [ie, osteoporosis associated with pulmonary silicosis]) may have deformities in multiple bones (eg, scapulae and pelvic bones), osteoarthrosis of cervical vertebrae, nondisplaced rib fractures, or complete
-FDG to assess disease activity in rheumatoid arthritis. This appeared as a promising tool for understanding the pathogenesis of the disease and help with therapy selection. 43 , 44 18 F-NaF PET has been used for assessment of osteoporosis 45 – 47 and
Abstract
Objective—To determine whether feeding a commercial anionic dietary supplement as a urinary acidifier to male goats may be useful for management of urolithiasis.
Animals—8 adult sexually intact male Toggenburg, Saanen, and Nubian goats.
Procedure—Goats were randomly assigned by age-, breed-, and weight-matched pairs to an oat or grass hay diet that was fed for 12 days. On days 13 to 14 (early sample collection time before supplementation), measurements were made of blood and urine sodium, potassium, calcium, magnesium, chloride, phosphorus, and sulfur concentrations; blood and urine pH; urine production; and water consumption. During the next 28 days, the anionic dietary supplement was added to the oat and grass hay diets to achieve a dietary cation-anion difference of 0 mEq/100g of dry matter. Blood and urine samples were analyzed during dietary supplementation on days 12 to 13 (middle sample collection time) and 27 to 28 (late sample collection time).
Results—Blood bicarbonate, pH, and urine pH of goats fed grass hay and goats fed oat hay were significantly decreased during the middle and late sample collection times, compared with the early sample collection time. Water consumption and urine production in all goats increased significantly during the late sample collection time, compared with the early sample collection time.
Conclusions and Clinical Relevance—The anionic dietary supplement used in our study increases urine volume, alters urine ion concentrations, and is an efficacious urinary acidifier in goats. Goats treated with prolonged anionic dietary supplementation should be monitored for secondary osteoporosis from chronic urinary calcium loss. (Am J Vet Res 2004;65:1391–1397)
may initiate a sequence of events that eventually results in the condition; a recent study 4 of 9 horses with this BFD that underwent necropsy examination identified histopathologic evidence of osteoporosis and abnormal osteoclast-mediated bone
accelerated bone turnover (osteoporosis and Paget's disease of bone). In addition, bisphosphonates are potent inhibitors of tumor-induced bone resorption and are commonly used in human patients with cancer (myeloma, breast cancer, and prostate cancer). 2 On
is growing concern about the incidence of osteopenia in dogs because of increases in lifespan. Therefore, osteopenia and osteoporosis induced by hyperadrenocorticism or exogenous prednisolone administration should be prevented by appropriate medical
, material properties, modeling and remodeling, and the effects of aging on osteoporosis. In the field of redox biology, investigators identify the role of redox proteins in the pathophysiology of ischemic diseases and age-related disorders, particularly
Bone mineral density is the mean concentration of mineral in a bone structure, and osteopenia and osteoporosis are conditions in which BMD is decreased. 1 Quantitative CT and dual energy x-ray absorptiometry have been used to measure BMD in
bone, findings in this dog were unusual because multiple myeloma lesions are typically characterized by osteolysis or osteoporosis. 1–3 The classic radiographic appearance of bone lesions in animals with multiple myeloma includes punched-out areas of
