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differentiated blasts with occasional mitosis in the red pulp and marginal zone ( Figure 3 ) . Based on these findings, acute myeloid leukemia (AML) with neutrophilic differentiation in bone marrow and spleen was diagnosed. Figure 1 Photomicrographs of

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in Journal of the American Veterinary Medical Association

HBSS Hank's balanced salt solution MFI Mean fluorescent intensity MPSS Methylprednisolone sodium succinate PMN Polymorphonuclear neutrophilic leukocyte ROS Reactive oxygen species a. Solumedrol, Pfizer, NY. b. Sigma-Aldrich Co, St

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in American Journal of Veterinary Research

linoleic acid PMN Polymorphonuclear neutrophilic leukocyte OBA Oxidative burst activity NAC N -acetylcysteine a. ProPlan, Nestlé Purina PetCare Korea Ltd, Seoul, Republic of Korea. b. SOLU-MEDROL INJ, Pfizer Pharmaceuticals Korea, Seoul

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in American Journal of Veterinary Research

high-dose MPSS treatment can temporarily suppress the innate immune functions of neutrophilic leukocytes. 19,20 Balanced nutrition is important for maintaining health and managing various diseases in animals. 21 Cells involved in immunity require

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in American Journal of Veterinary Research

elucidate the role of pANCAs in the development of these diseases. Abbreviations ANCA Anti-neutrophilic cytoplasmic autoantibody CI Confidence interval pANCA Perinuclear anti-neutrophilic cytoplasmic autoantibody PLE Protein

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in American Journal of Veterinary Research

Abstract

Objective—To describe diseases, prognosis, and clinical outcomes associated with extreme neutrophilic leukocytosis in cats.

Design—Retrospective study.

Animals—104 cats with extreme neutrophilic leukocytosis.

Procedure—Medical records from 1991 to 1999 were examined to identify cats that had ≥ 50,000 WBC/µl with ≥ 50% neutrophils. Signalment, absolute and differential WBC counts, rectal temperature, clinical or pathologic diagnosis, duration and cost of hospitalization, and survival time were reviewed.

Results—Mean age of cats was 8.3 years, mean WBC count was 73,055 cells/µl, and mean absolute neutrophil count was 59,046 cells/µl. Mean duration of hospitalization was 5.9 days, and mean cost of hospitalization was $2,010. Twenty-nine (28%) cats were febrile, and 63 (61%) cats died. Overall median survival time was 30 days. Cats with neoplasia were nearly 14 times as likely to die unexpectedly as cats with other diseases.

Conclusions and Clinical Relevance—Extreme neutrophilic leukocytosis was associated with a high mortality rate. The prognostic importance of extreme neutrophilic leukocytosis should not be overlooked. Cats and dogs have similar diseases, mortality rates, and treatment costs associated with extreme neutrophilic leukocytosis. (J Am Vet Med Assoc 2001;218:736–739)

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in Journal of the American Veterinary Medical Association

another study, 5 and it has since been reported that CSF associated with meningioma commonly is characterized by predominantly neutrophilic pleocytosis, 6–8 often with TNCCs > 50 cells/μL. 6,7 Results of these reports are contrary to the clinical

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in Journal of the American Veterinary Medical Association

criteria on which to base a definition of an inflammatory response in bronchial brushings. For the purposes of the study reported here, neutrophilic and eosinophilic inflammation in bronchial brushings were defined as values ≥90th percentile for the

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in American Journal of Veterinary Research

, whereas neutrophilic uveitis is often secondary to trauma or associated with bacterial infections. 5,7 Diffuse iris melanoma, the most commonly diagnosed feline intraocular tumor, 8 results from neoplastic transformation of melanocytes and has been

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in American Journal of Veterinary Research

, normochromic, nonregenerative anemia ( P < 0.001); neutrophilic leukocytosis ( P = 0.047); hyperproteinemia ( P = 0.037); and high serum alkaline phosphatase activity ( P < 0.001) were significantly more common in dogs with clinical spirocercosis than in

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in Journal of the American Veterinary Medical Association