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–2015 303 90 2016–2019 358 131 2020–2022 206 135 Total 1,030 447 Table 2 Distribution of minimum inhibitory concentrations necessary to inhibit the growth of 50% and 90% (MIC 50 and MIC 90 , respectively) of E

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in American Journal of Veterinary Research

clinical implications of these differences. ABBREVIATIONS MIC Minimum inhibitory concentration MIC 50 Minimum inhibitory concentration required to inhibit growth of 50% of bacterial isolates tested MIC 90 Minimum inhibitory concentration

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in American Journal of Veterinary Research

concentration–time curve in plasma AUC tears Area under the drug concentration–time curve in tear fluid Cmax Maximum concentration MIC Minimum inhibitory concentration Tmax Time of maximum concentration a. Nuflor, 300 mg/mL, MSD Santé Animale

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in American Journal of Veterinary Research

max ranged from 1.56 to 4.3 hours, and the t ½ was between 1 hour and 3 hours. These values attained the minimum inhibitory concentration (MIC) reported for 100% of pathogenic Aspergillus spp. 17 , 18 , 23 Discussion Voriconazole is

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in American Journal of Veterinary Research

See Tables 1 and 2 for key. Minimum inhibitory concentration distributions were variable among trials. The overall MIC of tilmicosin required to inhibit growth of 50% of M haemolytica and P multocida organisms was 4 μg/mL, whereas the MIC

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To determine the disposition of orally administered cefpodoxime proxetil in foals and adult horses and measure the minimum inhibitory concentrations (MICs) of the drug against common bacterial pathogens of horses.

Animals—6 healthy adult horses and 6 healthy foals at 7 to 14 days of age and again at 3 to 4 months of age.

Procedure—A single dose of cefpodoxime proxetil oral suspension was administered (10 mg/kg) to each horse by use of a nasogastric tube. In 7- to 14-day-old foals, 5 additional doses were administered intragastrically at 12-hour intervals. The MIC of cefpodoxime for each of 173 bacterial isolates was determined by use of a commercially available test.

Results—In 7- to 14-day-old foals, mean ± SD time to peak serum concentration (Tmax) was 1.7 ± 0.7 hours, maximum serum concentration (Cmax) was 0.81 ± 0.22 µg/mL, and elimination half-life (harmonic mean) was 7.2 hours. Disposition of cefpodoxime in 3- to 4-month-old foals was not significantly different from that of neonates. Adult horses had significantly higher Cmax and significantly lower Tmax, compared with values for foals. The MIC of cefpodoxime required to inhibit growth of 90% of isolates for Salmonella enterica, Escherichia coli, Pasteurella spp, Klebsiella spp, and β-hemolytic streptococci was 0.38, 1.00, 0.16, 0.19, and 0.09 µg/mL, respectively.

Conclusions and Clinical Relevance—Oral administration at a dosage of 10 mg/kg every 6 to 12 hours would appear appropriate for the treatment of equine neonates with bacterial infections. (Am J Vet Res 2005;66:30–35)

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in American Journal of Veterinary Research

Minimum inhibitory concentration t max Time to reach peak plasma doxycycline concentration a. Hapasil, Intervet Schering-Plough, Bowmeer, The Netherlands. b. Syvadox-10 (10% doxycycline hyclate), Syva Laboratories, León, Spain. c. Venoject

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in American Journal of Veterinary Research

pharmacodynamic model LC-LHL Low peak concentration—long elimination half-life LOQ Limit of quantification MIC Minimum inhibitory concentration a. Becton-Dickinson, Franklin Lakes, NJ. b. Corning Costar 96-well plates, Sigma-Aldrich, St Louis, Mo

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in American Journal of Veterinary Research

identification and antimicrobial susceptibility testing are recommended. ABBREVIATIONS NRSP-7 National Research Support Project No. 7 MIC Minimum inhibitory concentration CLSI Clinical and Laboratory Standards Institute ATCC

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in Journal of the American Veterinary Medical Association

-life λ Slope of the terminal phase AUC 0-12 AUC from 0 to 12 hours AUC 0-∞ AUC extrapolated to infinity MIC 90 Minimum inhibitory concentration-90% a. Doxycycline hyclate tablets, 500 mg, West-ward Pharmaceutical Corp

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in American Journal of Veterinary Research