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structures enriched in proteins, DNA, lipids, and RNA, including microRNA (miR). 11 miRs are noncoding short single-stranded RNAs that modulate cell differentiation and proliferation by regulating gene expression posttranscriptionally through the degradation

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in American Journal of Veterinary Research
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disease and released in proportion to the stage of heart disease are needed to determine the stage of MMVD, enhance the accuracy of diagnosis, and reliably predict the prognosis of dogs with CHF secondary to MMVD. MicroRNAs are recognized as crucial

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in American Journal of Veterinary Research

changes in function, facilitating treatment decisions. A promising group of biomarker candidates for kidney injury are microRNAs (miRNAs), which are small, noncoding RNAs that affect posttranscriptional regulation via interactions with mRNAs. 12 , 13

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in American Journal of Veterinary Research

technical assistance. ABBREVIATIONS Ct Threshold cycle EV Extracellular vesicle miRNA MicroRNA qRT Quantitative reverse transcription Footnotes a. Venoject II, VP-NA050K, Terumo Corp, Tokyo, Japan. b. S52ST rotor, Hitachi Inc

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in American Journal of Veterinary Research

known to regulate cellular responses and host pathways including malignancy. 14 , 15 MicroRNAs affect posttranscriptional regulation via binding of mRNAs, either preventing their translation into proteins or causing their degradation. Substantial

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in American Journal of Veterinary Research

MicroRNAs are small noncoding molecules that regulate gene expression following transcription and are involved in the control of various cellular mechanisms, including tumorigenesis and the development of various types of cancers. 1,2 A wide

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in American Journal of Veterinary Research

investigation in warranted, we believe results of this study provide support for the potential usefulness of miRNAs as diagnostic biomarkers for identification of dogs with TCC. ABBREVIATIONS CI Confidence interval miRNA MicroRNA MTT 3

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in American Journal of Veterinary Research

disease. 6 , 8 MicroRNAs (miRNAs) make up the majority of the nucleic acids and play a critical role in intercellular communication, especially between chondrocytes and synoviocytes in the context of the joint. 9 , 10 Thus, EVs are ideal candidates to be

Open access
in Journal of the American Veterinary Medical Association

recipient cells at the mRNA level. Thus, exosomal shuttle RNA, as functional molecules, may modulate the functionality of recipient cells via delivery of a specific set of microRNA (miRNA), a subset of these RNAs found within exosomes. 3 Furthermore

Open access
in Journal of the American Veterinary Medical Association

prognostic biomarkers, including protein and microRNAs for cancers in animals and in animal models for humans. Investigators in the Immune Regulation and Stem Cell Laboratory are determining the mechanisms that keep the immune system from attacking self

Open access
in American Journal of Veterinary Research