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inability to access the limbs in awake, defensive hedgehogs make SC injections more practical than IM and IV injections. Recent studies 2 , 3 have demonstrated that SC opioid administration can provide long-lasting antinociception in hedgehogs. Methadone

Open access
in American Journal of Veterinary Research

-approved opioid analgesics with label indications for use in dogs in the United States. Methadone is a μ-opioid receptor agonist that is approved by the FDA for analgesic use in people and that is approved in some countries for injectable use in dogs. In dogs

Open access
in American Journal of Veterinary Research

Methadone is a widely used pure μ-opioid receptor agonist in human and veterinary medicine. It is assumed to be adequate for severe pain because its pharmacological properties are similar to morphine and its antinociceptive potency is 10 to 50

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in Journal of the American Veterinary Medical Association

distribution and short terminal half-life. 7 , 8 , 9 Methadone is a μ-opioid receptor agonist and also an antagonist of N -methyl- d -aspartate receptors. 10 These 2 complementary mechanisms may contribute to an analgesic and anesthetic-sparing effect in

Full access
in American Journal of Veterinary Research

–4 Methadone has a short duration of action when administered parenterally and has a low bioavailability after oral administration in dogs. 5,6 A strategy to increase the plasma drug concentrations and duration of methadone's effects would be to include a

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in American Journal of Veterinary Research

butorphanol, have been evaluated in cats 5–11 ; however, the use of methadone, a synthetic opioid, in this species has received less attention. Early reports 12,13 indicated that this drug may potentially be useful as an analgesic, likely because of its

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in American Journal of Veterinary Research

tract, and genetic factors (eg, transporter proteins). 7 Methadone is an effective opioid agent that has unique properties and is used to treat severe acute and chronic, neuropathic, and cancer-related pain in humans. 8–11 Inter- and intraindividual

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in American Journal of Veterinary Research

Methadone is a μ-opioid receptor agonist that has been approved in countries other than the United States for the control of postoperative pain in dogs. It is labeled for I V, IM, and SC administration with an approximate duration of action of 4

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in American Journal of Veterinary Research

used as a relatively noninvasive marker of central opioid effects. Methadone is an opioid approved in some countries as a safe and effective analgesic for parenteral administration in dogs. The pharmacokinetics of methadone in dogs have been well

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in American Journal of Veterinary Research

standard against which all others are compared. Methadone is similar to morphine in potency but highly lipid soluble. Buprenorphine is a partial opioid μ-receptor agonist producing long-lasting analgesia. 15–18 Sympathetic stimulation and CNS excitation

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in American Journal of Veterinary Research