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research. Studies 5,6 have addressed the healing of equine musculoskeletal injuries through MSC-based treatments. Mesenchymal stem cells are an option for clinical application because they can be effectively isolated and expanded with high efficiency. 7

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in American Journal of Veterinary Research

. Cells were passaged and treated with MSC medium with or without IFN-γ a (100 ng/mL). 13,18 Mesenchymal stem cells were collected immediately before (baseline) and after 24, 48, and 96 hours of incubation for flow cytometry and qRT-PCR analysis. The

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in American Journal of Veterinary Research

hydrogel has also been considered for use in cartilage, 9,13 bone, 14 ligament, 15 and tendon 16 tissue engineering. Mesenchymal stem cells encapsulated in fibrin hydrogels maintain viability and proliferate. 17,18 Fibrin hydrogel can support

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in American Journal of Veterinary Research

cells. Induced pluripotent stem cells are multipotent and therefore able to form any cell type and indeed can form organ-like structures termed organoids. 2 Mesenchymal stem cells (MSCs) are multipotent cells derived from adult tissue of mesenchymal

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in Journal of the American Veterinary Medical Association

distal tarsal joints, forelimb proximal interphalangeal joints, and metacarpophalangeal joints is a common cause of reduced performance in dressage horses. 4 Mesenchymal stem cells have received a great deal of attention in recent years regarding

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in American Journal of Veterinary Research

prelude to clinical studies of CNS disorders in humans. ABBREVIATIONS MSC Mesenchymal stem cell FACS Fluorescence-assisted cell sorting FITC Fluorescein isothiocyanate MHC Major histocompatibility complex IBMX

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in American Journal of Veterinary Research

of autologous cells such as bone marrow stromal cells, which have been characterized as MSCs. 11 Recently, the use of autologous bone marrow–derived MSCs to treat superficial flexor tendon injuries has been reported. 12 Mesenchymal stem cells have

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in American Journal of Veterinary Research

tissue injuries and ischemic diseases. ABBREVIATIONS ASC Adipose tissue–derived mesenchymal stem cell EGM-2 Endothelial growth medium-2 FACS Fluorescence-activated cell sorting EPC Endothelial progenitor cell FBS Fetal bovine serum

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in American Journal of Veterinary Research

articular cartilage. 7 Mesenchymal stem cells are pluripotential cells capable of differentiating into multiple types of connective tissue cells. 8 Mesenchymal stem cells have been recognized as an attractive resource for the repair of musculoskeletal

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in American Journal of Veterinary Research

Extracellular matrix GAG Glycosaminoglycan HA Hyaluronic acid MSC Mesenchymal stem cell MW Molecular weight SEM Scanning electron microscopy TGF Transforming growth factor a. D1 ORL UVA, American Type Culture Collection, Manassas, Va. b

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in American Journal of Veterinary Research