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tendon injuries. Figure 1 Licensing strategies to improve the effector function of naïve mesenchymal stem cells (MSCs). Created with BioRender.com. Effector Function of Licensed MSCs Innate immune cell modulation Immune cells of both

Open access
in American Journal of Veterinary Research

. For all these reasons, novel therapies to improve tendon healing and reduce failure and reinjury rates are needed. The purpose of this manuscript is to review the evidence available for the use of mesenchymal stem cells (MSCs) to improve tendon healing

Open access
in Journal of the American Veterinary Medical Association

T here remains a critical need to more thoroughly elucidate the mesenchymal stem cell (MSC) mechanism of action to improve their utilization as a cellular therapy. This is apparent in recent research, which has steered a paradigm shift toward

Open access
in Journal of the American Veterinary Medical Association

(EVs) released from mesenchymal stem cells (MSCs) are responsible for many of the bioactive properties of the cells. These EVs could play a significant role in decreasing inflammation within the joint and reducing the negative effects of inflammatory

Open access
in Journal of the American Veterinary Medical Association

research. Studies 5,6 have addressed the healing of equine musculoskeletal injuries through MSC-based treatments. Mesenchymal stem cells are an option for clinical application because they can be effectively isolated and expanded with high efficiency. 7

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in American Journal of Veterinary Research

. Cells were passaged and treated with MSC medium with or without IFN-γ a (100 ng/mL). 13,18 Mesenchymal stem cells were collected immediately before (baseline) and after 24, 48, and 96 hours of incubation for flow cytometry and qRT-PCR analysis. The

Full access
in American Journal of Veterinary Research

hydrogel has also been considered for use in cartilage, 9,13 bone, 14 ligament, 15 and tendon 16 tissue engineering. Mesenchymal stem cells encapsulated in fibrin hydrogels maintain viability and proliferate. 17,18 Fibrin hydrogel can support

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in American Journal of Veterinary Research

cells. Induced pluripotent stem cells are multipotent and therefore able to form any cell type and indeed can form organ-like structures termed organoids. 2 Mesenchymal stem cells (MSCs) are multipotent cells derived from adult tissue of mesenchymal

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in Journal of the American Veterinary Medical Association

distal tarsal joints, forelimb proximal interphalangeal joints, and metacarpophalangeal joints is a common cause of reduced performance in dressage horses. 4 Mesenchymal stem cells have received a great deal of attention in recent years regarding

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in American Journal of Veterinary Research

prelude to clinical studies of CNS disorders in humans. ABBREVIATIONS MSC Mesenchymal stem cell FACS Fluorescence-assisted cell sorting FITC Fluorescein isothiocyanate MHC Major histocompatibility complex IBMX

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in American Journal of Veterinary Research