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F eline mesenchymal stem cells (MSCs; sometimes referred to as mesenchymal stromal cells) were first mentioned in the literature in 2002. 1 Significant interest has been placed on the potential of MSC and related animal cell and tissue

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in Journal of the American Veterinary Medical Association

S ignificant interest has been placed on the potential of mesenchymal stem cells (MSCs) and related animal cell and tissue-based products (ACTPs) to address unmet therapeutic needs in veterinary and human medicine. Despite the promise and the

Open access
in Journal of the American Veterinary Medical Association

Introduction Retroperitoneal sarcomas (RPSs) comprise a heterogenous group of rare mesenchymal tumors arising from the structures within the retroperitoneal space. Within this retroperitoneal space the major organs include the kidneys, ureters

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in Journal of the American Veterinary Medical Association

research. Studies 5,6 have addressed the healing of equine musculoskeletal injuries through MSC-based treatments. Mesenchymal stem cells are an option for clinical application because they can be effectively isolated and expanded with high efficiency. 7

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in American Journal of Veterinary Research

cells. Induced pluripotent stem cells are multipotent and therefore able to form any cell type and indeed can form organ-like structures termed organoids. 2 Mesenchymal stem cells (MSCs) are multipotent cells derived from adult tissue of mesenchymal

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in Journal of the American Veterinary Medical Association

. Cells were passaged and treated with MSC medium with or without IFN-γ a (100 ng/mL). 13,18 Mesenchymal stem cells were collected immediately before (baseline) and after 24, 48, and 96 hours of incubation for flow cytometry and qRT-PCR analysis. The

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in American Journal of Veterinary Research

hydrogel has also been considered for use in cartilage, 9,13 bone, 14 ligament, 15 and tendon 16 tissue engineering. Mesenchymal stem cells encapsulated in fibrin hydrogels maintain viability and proliferate. 17,18 Fibrin hydrogel can support

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in American Journal of Veterinary Research

distal tarsal joints, forelimb proximal interphalangeal joints, and metacarpophalangeal joints is a common cause of reduced performance in dressage horses. 4 Mesenchymal stem cells have received a great deal of attention in recent years regarding

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in American Journal of Veterinary Research

groups. A value of P < 0.05 was considered to be significant. Results Morphological and immunophenotypic changes —Endothelial differentiation was induced by culturing canine ASCs in EGM-2 media. Undifferentiated ASCs had typical mesenchymal

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in American Journal of Veterinary Research

prelude to clinical studies of CNS disorders in humans. ABBREVIATIONS MSC Mesenchymal stem cell FACS Fluorescence-assisted cell sorting FITC Fluorescein isothiocyanate MHC Major histocompatibility complex IBMX

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in American Journal of Veterinary Research