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Introduction Vinblastine is a vinca alkaloid used in veterinary medicine for the treatment of canine mast cell tumors (MCTs). A conventional chemotherapy protocol for treating high-grade or metastatic canine MCTs consists of 8 vinblastine
surgery for the treatment of canine cutaneous mast cell tumours . J Small Anim Pract 2000 ; 41 : 7 – 11 . 10.1111/j.1748-5827.2000.tb03128.x 21. Ferrer L . Treatment of cutaneous mast cell tumors, in Proceedings. North Am Vet Conf , 2005 : 247
Introduction Mast cell tumors (MCTs) are the most common cutaneous neoplasia reported in dogs. 1 , 2 Opioids are often administered for analgesia as part of the anesthesia protocol for MCT excision. 3 , 4 Opioids such as morphine can help
tumors in dogs . J Am Vet Med Assoc 1996 ; 209 : 1418 - 1420 . 7. Bostock DE Crocker J Harris K , et al Nucleolar organiser regions as indicators of post-surgical prognosis in canine spontaneous mast cell tumours . Br J Cancer 1989
Mast cell tumors are common tumors of the skin, intestinal tract, and spleen in cats. 1 The biological behavior of MCTs in cats ranges from benign to malignant. Most cutaneous MCTs are benign, and recurrence or metastasis after excision or
ill or clinically normal, no mast cells were detected in any of the buffy coat smears. Discussion Mast cell tumors are a common neoplasm in cats, occurring less frequently than only lymphoma and mammary adenocarcinoma in 1 study. 14 The
. Blackwood L , Murphy S , Buracco P , et al . European consensus document on mast cell tumours in dogs and cats . Vet Comp Oncol . 2012 ; 10 : e1 – e29 . 2. Thamm DH , Vail DM. Mast cell tumors . In: Withrow SJ , Vail DM , eds
Mast cell tumor is the most commonly diagnosed malignant skin tumor in dogs. 1,2 Cutaneous mastocytoma is the most common type of MCT and originates from mast cells in the dermis and subcutaneous tissue 3 ; however, MCT can potentially originate
Introduction Soft tissue sarcomas (STS) and mast cell tumors (MCT) are two of the most common cutaneous and subcutaneous malignant tumors in dogs. An important prognostic factor for each of these tumor types is histologic grade, with higher
SUMMARY
In a controlled study, malignant murine P815 mastocytoma cells exposed in vitro to distilled and deionized water died as a result of progressive swelling, degranulation, and membrane rupture. A 90% mean cell death occurred when cells obtained directly from culture were exposed to deionized water for 2 minutes. Of 6 cryopreserved malignant murine cell lines, which included Cloudman S91 melanoma, CMT-93 rectum carcinoma, MMT-06052 mammary carcinoma, and S-180 Sarcoma, only P815 mastocytoma and YAC-1 lymphoma were significantly (P < 0.05) affected by hypotonic shock; Cloudman S91 melanoma cells were the most resistant. Mastocytoma cells were selectively killed by hypotonic solution, and lymphoma cells were also killed by isotonic saline solution.
Local mast cell tumor (mct) recurrence and percentage survival were evaluated in 12 cats (21 mct) and 54 dogs (85 mct) subjected to surgery alone or local infiltration of deionized water as an adjunct to surgery. Of all 16 incompletely excised mct in cats, there was no local recurrence following injection. Four mast cell tumors (2 cats) regressed after being injected in situ. In dogs with clinical stage-I mct, local recurrence was detected in 50% (5/10), but with injection after incomplete excision, local mct recurrence was significantly (P < 0.05) less (6.6%, 1/15). Percentage recurrence was significantly (P < 0.05) less and survival significantly greater when incompletely excised grade-II mct were injected. Mean follow-up period after surgery in cats and dogs was 35 and 23.4 months, respectively.
