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in people, suggesting a causal relationship between hypercalcemia and the development of AP at least in people. 7 , 8 The effect of the resolution of hypercalcemia on pancreatic lipase (cPLI) concentrations in dogs is unknown. Humans with recurrent
L ipases are water-soluble enzymes that hydrolyze ester bonds of water-insoluble substrates, such as triglycerides, into diglycerides, monoglycerides, and fatty acids ( Figure 1 ) . Lipases belong to a superfamily of enzymes that share a
. 2,3 Determination of serum lipase activity has been used for diagnosis of pancreatitis in humans and dogs for several decades. 4–7 However, in both species, it is well recognized that serum lipase activity is neither sensitive nor specific for
addition to measurement of pancreatic lipase concentrations or activity in serum or plasma. 2 Under normal physiologic conditions, the vast majority (approx 99%) of pancreatic lipase and colipase is released from the apical pole of the pancreatic acinar
–specific lipase 5 concentration determination and pancreatic ultrasonography 6 are the 2 tests generally considered key tools for diagnosing pancreatitis in cats. The feline pancreas–specific lipase assay is generally believed to represent the most sensitive
For decades serum lipase activity has been used for diagnosing pancreatitis in dogs and humans. 1–4 However, serum lipase activity is neither sensitive nor specific for pancreatitis in either species. Lipases are produced by many cell types in
to disease localization, the frequency of the antemortem diagnosis of pancreatitis in cats has increased with advances in pancreatic serology and imaging. 3 , 14 , 15 , 27 , 30 A polyclonal sandwich radioimmunoassay for feline pancreatic lipase
, hyperkalemia, and serum fPLI concentration at the time of hospital admission were independent prognostic indicators for outcome. ABBREVIATIONS fPLI Feline pancreatic lipase immunoreactivity SIRS Systemic inflammatory response syndrome a
is aided by a point-of-care semiquantitative test that measures serum concentration of pancreas-specific lipase (SNAP cPL test kit; Idexx Laboratories Inc) and was developed to screen patients at the time of initial presentation. Results of the SNAP
CI Confidence interval fPLI Feline-specific pancreatic lipase immunoreactivity HRS High-rise syndrome a. Dupre G, Allenou A, Bouvy B. High-rise syndrome: a retrospective study on 413 cats (abstr). Vet Surg 1995;24:294. b. Forman MA
