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is the potential association between pancreatitis and an increased prevalence of chronic kidney disease (CKD). Chronic kidney disease in cats is defined and staged via serum creatinine levels using the International Renal Interest Society (IRIS

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in Journal of the American Veterinary Medical Association

. 38 Fructosamine 3-kinase requires ATP as a cofactor and is therefore only found intracellularly. 39 To date, an extracellular enzyme has not been discovered. Fructosamine 3-kinase has been found in numerous tissues, but the brain, heart, kidneys

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate a group of vaccine site-associated sarcomas (VSS) for the presence of feline foamy virus (FeFV) DNA, using polymerase chain reaction (PCR) methods.

Sample Population—50 formalin-fixed paraffin embedded (FFPE) tissue blocks from VSS of cats.

Procedure—DNA was extracted from FFPE sections of each tumor, and regions of the gag and pol genes of FeFV were amplified by use of PCR methods, using 1 primer set for each region. Sensitivity of the method was compared between fresh and FFPE cells, using mouse kidney tissue that was injected with FeFVinfected cultured cells and using agarose-cell pellets.

Results—Feline foamy virus DNA was not detected in VSS tissues. Sensitivity of the method was 10 times greater in fresh versus FFPE mouse tissues. Sensitivity of the method in fresh FeFV-infected cultured cells versus FFPE agarose-cell pellets was equal when fixation was 24 or 48 hours and 10 times greater when fixation was 72 hours or 1 week.

Conclusion and Clinical Relevance—A PCR-based method can be successfully applied to FFPE tissues for FeFV DNA detection. Results suggest there is no direct FeFV involvement in the pathogenesis of VSS in cats. (Am J Vet Res 2002;63:60–63)

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in American Journal of Veterinary Research

for SDMA have also been described in green sea turtles ( Chelonia mydas ). 12 However, the clinical relevance of this marker remains unclear in reptiles. A recent study 13 has shown that GGT and ALT activities were higher in the kidneys of healthy

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in American Journal of Veterinary Research

Diagnostic imaging methods are commonly used to estimate kidney size. The most commonly used measurement for this purpose in clinical practice is the ratio of kidney length to the length of the L2 vertebral body on a ventrodorsal radiograph; this

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in American Journal of Veterinary Research

a decrease in the production of prostanoids. In the kidneys, prostaglandins have a role in regulation of GFR, renin release, and sodium excretion. 6 Prostaglandins are synthesized by both COX-1 and COX-2 in healthy kidneys; however, when angiotensin

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in American Journal of Veterinary Research

C linical trials in cats with naturally occurring chronic kidney disease (CKD) are critical to advance new diagnostic and therapeutic opportunities. Evaluation of client-owned cats presents challenges, including variable husbandry practices

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in American Journal of Veterinary Research

Chronic kidney disease is common in aged domestic cats, with prevalence estimates ranging up to 30% to 50%. 1,2 Histologically, CKD in cats is characterized by tubulointerstitial fibrosis, 3 a finding that is strongly correlated with functional

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in American Journal of Veterinary Research

Introduction Chronic kidney disease (CKD) has been shown to be one of the most prevalent diseases in felid species, including domestic cats and many nondomestic felids. 1 – 3 Antemortem serum and urinary biochemical diagnosis of renal disease

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in Journal of the American Veterinary Medical Association

Giant kidney worms ( Dioctophyme renale ) are parasitic roundworms reported most often in dogs 1–9 and wild carnivores 10,11 and less frequently in cats, 12 rats, 13 and humans. 14–16 The life cycle of the parasite requires an oligochete

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in Journal of the American Veterinary Medical Association