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Bone infarcts are areas of osteonecrosis that develop as a result of ischemia. 1 Typical histologic findings such as focal loss of vascular perfusion, edema, adipocyte necrosis, and proliferation of fibroblasts from bone marrow stromal cells can

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in Journal of the American Veterinary Medical Association

pancreatitis in humans, although the direction of causation is unclear. 21 In humans, renal infarcts are a recognized consequence of cardioembolic disease, atrial fibrillation, renal artery injury, fibromuscular dysplasia, hypercoagulable states potentially

Open access
in Journal of the American Veterinary Medical Association

SUMMARY

The effects of iv administered amiodarone, a class-III antiarrhythmic agent, on myocardial contractility, early myocardial relaxation, and hemodynamic variables were evaluated in normal canine hearts and those with infarcts. In the normal canine heart, amiodarone had important, but relatively mild, depressant effects on left ventricular contractility (assessed by maximal positive first derivative of left ventricular pressure (+ dP/dtmax) and maximal elastance (Emax)) and heart rate when given iv at a dose of 10 mg/kg of body weight. An effect on contractility or active relaxation (assessed by maximal negative first derivative of left ventricular pressure (— dP/dtmax) and the time constant of isovolumic pressure decrease) was not identified with smaller doses. Myocardial infarction itself caused a predictable and marked depressant effect on myocardial contractility, as indicated by decreases in + dP/dtmax, ejection fraction, Emax, and — dP/dtmax, and elevation in end diastolic pressure. Additional depressive effects on contractility and active relaxation resulted when 10 mg of amiodarone/kg was administered to dogs with myocardial infarction and these effects were sufficient to worsen acute myocardial infarction-induced heart failure. Significant changes attributable to heart rate alone could not be identified. On the basis of our findings, we suggest that amiodarone administered iv should be used with caution in dogs with compromised ventricular function.

Free access
in American Journal of Veterinary Research

infarcts ( Figure 1 ) . No other relevant macroscopic lesions were observed during necropsy. Histopathological examination of the abdominal aorta revealed the endothelium surface covered by several layers of platelets, fibrin, and erythrocytes (arterial

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in Journal of the American Veterinary Medical Association

possible splenomegaly. Abdominal ultrasonography identified a splenic infarct secondary to a thrombus at the tip of the spleen, edema in the fundic portion of the stomach consistent with the recent gastric surgery and involution, and a mild peritoneal

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in Journal of the American Veterinary Medical Association

bird recovered uneventfully. These MRI findings were compatible with an acute ischemic stroke with 2 brain infarcts. An inflammatory lesion was considered part of the differential diagnosis. Neoplasia was considered less likely because of the lack of

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in Journal of the American Veterinary Medical Association

approximately 6 mm into the surrounding soft tissues. Minimal soft tissue swelling is noted at the distal aspects of the radius and ulna. These findings are consistent with polyostotic medullary infarcts with an aggressive lesion of the distal aspect of the left

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in Journal of the American Veterinary Medical Association

Objective

To determine the prevalence of attenuated wavy fibers in the myocardium of dogs with and without dilated cardiomyopathy (DCM).

Design

Prevalence survey.

Animals

70 dogs clinically suspected to have DCM (ie, fractional shortening < 25%, absence of echocardiographic lesions other than chamber dilatation, and radiographic or postmortem evidence of congestive heart failure) and 147 dogs with chronic valvular disease (n = 60), congenital heart disease (49), myocardial infarcts (23), myocarditis (8), or endocarditis (7).

Procedure

Echocardiography and electrocardiography were performed, and thoracic radiographs were obtained with dogs in left lateral recumbency. Necropsy specimens were examined for attenuated wavy fibers (ie, myocardial cells < 6 μm in diameter with a wavy appearance).

Results

65 of 70 dogs clinically suspected to have DCM were confirmed to have the disease on postmortem examination, and 64 of 65 had attenuated wavy fibers. The remaining 5 dogs were found during postmortem examination to have heart disease other than DCM, and none had attenuated wavy fibers. Only 1 of 147 dogs with heart disease other than DCM had attenuated wavy fibers.

Clinical Implications

Findings suggest that histologic examination for attenuated wavy fibers may be a useful postmortem test for DCM in dogs. The diagnosis was confirmed in 65 of 70 dogs suspected to have DCM on the basis of standard clinical criteria. (J Am Vet Med Assoc 1998;212: 1732–1734)

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in Journal of the American Veterinary Medical Association

-mm-diameter intra-axial hemorrhagic lesion in the right temporal lobe as well as smaller right-sided ischemic infarcts in the thalamus and the cerebellum. Thoracic and abdominal CT before and after IV administration of iodinated contrast medium was

Open access
in Journal of the American Veterinary Medical Association