Histiocytic sarcoma (also known as malignant histiocytosis) is a neoplastic disorder arising from cells of the histiocytic lineage (macrophages and dendritic cells). 1–8 The disease is characterized by infiltration of many organs including the
Histiocytic sarcoma is a round-cell neoplasm associated with a poor prognosis in dogs. Advances in veterinary pathology and immunohistochemical techniques have enabled identification of the putative cell of origin and have resulted in the
Histiocytic sarcoma (HS) is a cancer of histiocytes (tissue cells), that is, dendritic cells or macrophages. As sentinels and scavengers of the innate immune system, these cells normally traffic through most body tissues
Histiocytic sarcomas of dogs are tumors originating from histiocytic cell lineages, including dendritic cells and macrophages. 1,2 Histiocytic sarcomas arise from interstitial dendritic cells and are subdivided into 2 categories: localized and
copy number aberrations (ie, gene dosage) in genomic DNA isolated from malignant cells. 13–22 Several consistent DNA copy number aberrations have been identified in samples of lymphomas, osteosarcomas, and histiocytic sarcomas of dogs. Regions of the
that for dogs with meningioma that do not receive aggressive treatment ranges from 2 to 2.5 months. 6,7
Intracranial histiocytic sarcoma is also an extra-axial tumor and has MRI characteristics that are similar to those of meningioma. 3,8 However
, tachypnea, labored breathing, signs of depression, and loss of appetite of 1 week's duration. A mammary mass had been removed 6 weeks earlier, and results of histologic examination of the mass were consistent with a diagnosis of localized histiocytic sarcoma
histiocytic sarcomas, fibrosarcomas, chondrosarcomas, osteosarcomas, hemangiopericytomas, and mast cell and neuroendocrine tumors, 4 , 5 , 7 , 8 , 9 , 10 suggesting the need for updated information regarding histopathologic types of PPN in dogs.
other breeds, 1 (2%) each. Median body weight for all dogs was 28.1 kg (61.8 lb), with a range of 5.0 to 66.0 kg (11 to 145.2 lb).
Twelve histologic types of tumor were represented as follows: primary pulmonary carcinoma, 31 (53%); histiocytic sarcoma