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to determine if PBM causes premature release of bupivacaine from liposomal bupivacaine suspensions. Our null hypothesis was that there would be no difference in free bupivacaine in samples treated with or without PBM therapy. Methods This study

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in American Journal of Veterinary Research

occurred at the 10 hour postblock time point. These data may suggest a similar nonlinear release rate of free bupivacaine from the vesicles, perhaps as a result of the rate of degradation and thus release of free drug into the perineural tissue. A similar

Open access
in American Journal of Veterinary Research

. Alternatively, the liposomes in the suspension perhaps could have been too large to migrate and distribute throughout the tissues as well as the slow release of free bupivacaine from the vesicles may also help explain this apparent lack of benefit. The

Open access
in American Journal of Veterinary Research

-temporal retrobulbar block consisting of 0.5% preservative-free bupivacaine g dosed at 2 mL for dogs weighing up to 15 kg (33 lb) and 3 mL for dogs > 15 kg. The dose of bupivacaine was intentionally adjusted to < 2.0 mg/kg (0.9 mg/lb) to avoid the possibility of local

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in Journal of the American Veterinary Medical Association

of preservative-free bupivacaine vs. lidocaine for intracameral anesthesia: a randomized clinical trial and in vitro analysis . Am J Ophthalmol 1999 ; 127 : 393 – 402 . 10.1016/S0002-9394(98)00417-6 28. Hoffman RS Fine IH . Transient no

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in American Journal of Veterinary Research

below. Dogs in the RB group received a preoperative inferotemporal retrobulbar block of 0.5% preservative-free bupivacaine approximately 20 minutes prior to the start of surgery by a trained ophthalmology resident. Dosing was as follows: 2 mg

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in Journal of the American Veterinary Medical Association

. Treatment groups Chondrocytes were exposed to the following treatments: (1) media only (CON; DMEM/F12; Gibco) as a negative control; (2) bupivacaine (BUPI; preservative-free bupivacaine HCl; Hospira Inc) diluted in DMEM/F12 (2.2 mg/mL final concentration

Open access
in American Journal of Veterinary Research

bilateral TPLO procedures received an epidural (0.1 mg/kg morphine and 0.5 mg/kg preservative-free bupivacaine) in lieu of a femoral-sciatic block. A second, clean scrub (single-use examination gloves, 2% chlorhexidine scrub, and alcohol scrub for > 5

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in Journal of the American Veterinary Medical Association

further, and it was suggested that preservative-free bupivacaine should be used for intra-articular injection. 10 We are not aware of any other reports of studies conducted to evaluate the effects of intra-articular injection of bupivacaine containing

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in American Journal of Veterinary Research

/kg [0.34 mg/lb]), preservative-free bupivacaine hydrochloride (0.375 mg/kg [0.17 mg/lb]), and preservative-free morphine sulfate (0.1 mg/kg [0.045 mg/lb]) was administered at the L7-S1 intervertebral space. Cefazolin sodium (22 mg/kg [10 mg/lb]) was

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in Journal of the American Veterinary Medical Association