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lines were found, and some of the aggregates were associated with plump spindled mesenchymal cells and scant extracellular matrix ( Figure 1 ) . This cytology is consistent with extramedullary hematopoiesis (EMH), an expected response to the significant

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in Journal of the American Veterinary Medical Association

, Lanzi A , Marano G , et al . Paraparesis induced by extramedullary haematopoiesis . World J Radiol 2011 ; 3 : 82 – 84 . 10.4329/wjr.v3.i3.82 12. Saghafi M , Shirdel A , Lari SM . Extramedullary hematopoiesis with spinal cord

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in Journal of the American Veterinary Medical Association

divided into broad categories of malignant and benign splenic diseases. The histopathologic diagnoses of nodular hyperplasia, hematoma, and extramedullary hematopoiesis were combined for analysis because these processes typically occur simultaneously in

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To determine clinical and clinicopathologic features of a chronic intermittent severe hemolytic anemia characterized by erythrocyte osmotic fragility in Abyssinian and Somali cats.

Design—Case series.

Animals—13 Abyssinian and 5 Somali cats.

Procedures—History, pedigree information, and results of routine laboratory tests, special erythrocyte studies, and histologic evaluation of splenic and hepatic specimens were analyzed.

Results—Age at which clinical signs of anemia were first apparent ranged from 6 months to 5 years. Ten cats had splenomegaly. Most often, the PCV was between 15 and 25%, but it was as low as 5% at some times. The anemia was characterized by macrocytosis and mild to moderate reticulocytosis, but no poikilocytosis. Hyperglobulinemia, lymphocytosis, mild hyperbilirubinemia, and high hepatic enzyme activities were common findings. Results of Coombs tests and tests for infectious diseases were negative. The erythrocytic osmotic fragility was high in affected cats (mean osmotic fragility, 0.66 to 0.78%), compared with healthy cats (0.48 to 0.58). No specific membrane protein abnormality, erythrocyte enzyme deficiency, or hemoglobinopathy was identified. Histologic evaluation of splenic and hepatic specimens revealed extramedullary hematopoiesis and hemosiderosis. Four of the 5 Somali cats were closely related.

Conclusions and Clinical Relevance—On the basis of results of pedigree analyses, the apparent breed predilection, and the exclusion of other known causes of anemia in cats, we believe that the hemolytic anemia in these cats was likely a result of a novel hereditary erythrocyte defect. A genetic predisposition to immunemediated destruction of erythrocytes could not be ruled out. (J Am Vet Med Assoc 2000;217:1483–1491)

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in Journal of the American Veterinary Medical Association

masses in a dog evaluated because of progressive paraparesis and report that results of histologic examination of the masses were consistent with extramedullary hematopoiesis. We disagree with the authors' diagnosis and suggest, instead, that the dog

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in Journal of the American Veterinary Medical Association

urinalysis and abdominal ultrasonography performed 4 months after the initial examination indicated resolution of the disease. See page 798 Spinal cord compression secondary to extramedullary hematopoiesis in a dog Results of neurologic

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in Journal of the American Veterinary Medical Association

Bolton Center School of Veterinary Medicine Kennett Square, Pa Dural ossification (ossifying pachymeningitis) I read with interest the recent JAVMA article on spinal cord compression secondary to extramedullary hematopoiesis in a dog. 1

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in Journal of the American Veterinary Medical Association

of myeloid hyperplasia than it appears as a result of enlargement due to a combination of congestion and extramedullary hematopoiesis. Splenomegaly is a common lesion in ferrets and is often due to congestion, extramedullary hematopoiesis, lymphoid

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in Journal of the American Veterinary Medical Association

, hemangioma, nodular hyperplasia, extramedullary hematopoiesis, hematoma, and hemangiosarcoma. Radiographic findings were suggestive of a soft tissue mass, but the ultrasonographic attenuation of the hyperechoic mass suggested a fat-rich component. On the

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in Journal of the American Veterinary Medical Association

diagnoses for splenomegaly include extramedullary hematopoiesis, neoplasia (ie, lymphoma or mast cell disease), and inflammation. Figure 2— Same radiographic images as in Figure 1 . Notice the gas- and ingesta-filled pylorus (arrow) cranial and dorsal

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in Journal of the American Veterinary Medical Association