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, ASM proliferation. 14 – 16 Therefore, the expression of miR related to asthma pathogenesis and smooth muscle remodeling 17 was studied in neutrophil-derived exosomes, the smallest form of EVs, collected from horses affected by SEA and healthy animals

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in American Journal of Veterinary Research

components without direct cell-to-cell contact. Different EVs have been identified, including exosomes, microvesicles (ie, ectosomes or shedding vesicles), and apoptotic bodies. These vesicles differ in biogenesis, size, content, release mechanisms, and

Open access
in Journal of the American Veterinary Medical Association

that are classified based on their biogenesis and size as exosomes (approx 30 to 100 nm), microvesicles (approx 100 to 1,000 nm), and apoptotic vesicles (approx 1,000 to 5,000 nm). Exosomes are produced by the endosomal system and are the most

Open access
in Journal of the American Veterinary Medical Association

Exosomes as Alternatives to MSCs The capacity for MSCs to differentiate into multiple cellular lineages was originally believed to be the primary mechanism for MSC-mediated tissue healing and regeneration. 8 It is now widely accepted that the MSC

Open access
in Journal of the American Veterinary Medical Association

Extracellular vesicles are composed of a lipid bilayer that is produced by various cell types. These vesicles are primarily categorized by mode of biogenesis into 3 classes: exosomes, microvesicles, and apoptotic bodies. Exosomes are formed as the

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in American Journal of Veterinary Research

: 528 – 533 . 10.1016/j.bbrc.2010.04.135 4. Keller S Ridinger J Rupp AK , et al. Body fluid derived exosomes as a novel template for clinical diagnostics . J Transl Med 2011 ; 9 : 86 . 10.1186/1479-5876-9-86 5. Mitchell PS

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in American Journal of Veterinary Research

: 10.3390/ani10101723 5. He L , He T , Xing J , et al . Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis . Stem Cell Res Ther . 2020 ; 11 ( 1

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in Journal of the American Veterinary Medical Association

. Extracellular vesicles including exosomes are secreted by cells, spreading signals from cell to cell and circulating in blood. “Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring

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in Journal of the American Veterinary Medical Association

.1083/jcb.201310134 24215073 38. Alvarez-Erviti L , Seow Y , Yin H , Betts C , Lakhal S , Wood MJ . Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes . Nat Biotechnol . 2011 ; 29 ( 4 ): 341 – 345 . doi: 10

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in Journal of the American Veterinary Medical Association

contralateral kidney include circulating hormones, cytokines, or exosomes containing microRNAs, 52,53 none of which were assessed in the present study. In rats, experimental induction of transient ischemia followed by reperfusion of 1 kidney resulted in

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in American Journal of Veterinary Research