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SUMMARY

In a search of viral agents in pulmonary macrophages of horses with chronic pulmonary disease, equine herpesvirus 2 was found to be unique. In 8 of 9 horses with chronic pulmonary disease, antigens of equine herpesvirus 2 were detected by indirect immunofluorescence staining of scattered foamy macrophages immediately after harvesting by bronchoalveolar lavage and fractionation on metrizamide gradients. In a healthy horse, antigens were not found. After 1 week of cultivation of bronchoalveolar lavage cells from a second group of 9 horses with chronic pulmonary disease, viral antigens were detected in 90% of the adherent pulmonary macrophages. In 2 of 3 healthy horses, viral antigens also were found in 90% of the adherent pulmonary macrophages. Antigens of equine herpesvirus 1, equine herpesvirus 4, parainfluenza virus 3, or adenovirus were not detected. Antigens of the 5 investigated viruses also were not detected in lung tissue slices from a third group of 14 horses: 4 healthy; 7 with varying degrees of bronchiolitis, 2 of which also had chronic intestitial pneumonia; 2 with eosinophilic bronchitis; and 1 with pulmonary hemorrhage.

The exclusive presence of equine herpesvirus 2 in pulmonary macrophages was confirmed qualitatively by isolation of infective virus by cocultivation. In a fourth group of 12 horses with chronic pulmonary disease, infective virus could be isolated from pulmonary macrophages of 3 horses and from mixed- blood leukocytes of 5 horses. Virus isolations from 2 healthy horses were not successful from pulmonary macrophages, whereas 1 isolation was obtained from mixed-blood leukocytes. Other viruses were not detected by cocultivation.

Free access
in American Journal of Veterinary Research

that had equine glandular gastric disease (EGGD). Positive hybridization (pink to red staining, arrows) is observed scattered through the tissue. Horse 2; equine herpesvirus 2 (EHV-2) glycoprotein B ( gB ) ISH; bar = 500 µm; inset bar = 100 µm. B

Open access
in American Journal of Veterinary Research

herpesvirus 2 in pulmonary macrophages of horses . Am J Vet Res 1995 ; 56 : 749 – 754 . 25. Blakeslee JR Olsen RG McAllister ES , et al . Evidence of respiratory tract infection induced by equine herpesvirus, type 2, in the horse . Can J

Full access
in Journal of the American Veterinary Medical Association

herpesvirus (2/11). Although concurrent neurologic disease from an infectious agent is possible, it is likely that detection of antibodies in the horses of this study did not reflect active infection or was attributable to antigen cross-reactivity or to

Full access
in Journal of the American Veterinary Medical Association