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T he fluoroquinolones enrofloxacin (Baytril) and marbofloxacin (Zeniquin) were approved for use in dogs by the US Food and Drug Administration (FDA) in December 1988, and June 1999, respectively. The originally approved label for enrofloxacin

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in American Journal of Veterinary Research

Enrofloxacin belongs to the fluoroquinolone family, a group of synthetic antimicrobials derived from nalidixic and oxolinic acid. 1 As a group, fluoroquinolones have excellent activity against gram-negative bacteria including Pseudomonas

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in Journal of the American Veterinary Medical Association

principally by inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within bacterial cells. 7 Enrofloxacin, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihidro-4-oxo-3

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in American Journal of Veterinary Research

Enrofloxacin is a concentration-dependent fluoroquinolone with antimicrobial activity against mainly gram-negative and some gram-positive bacteria, and minimal activity against anaerobic bacteria. 1 Enrofloxacin might also be effective against

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in American Journal of Veterinary Research

reflected in similar pharmacokinetic behavior of drugs. Enrofloxacin is one of the most widely used fluoroquinolones in veterinary medicine. Because of its pharmacokinetic profile and spectrum of activity, enrofloxacin is an antimicrobial agent frequently

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in American Journal of Veterinary Research

indicate that antimicrobials have varying efficacy for the treatment of clinically ill sea stars in aquarium collections. Enrofloxacin is one of the most commonly used antimicrobials because of its broad spectrum of activity. Like other fluoroquinolones

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in American Journal of Veterinary Research

Because of their low toxicity and relatively broad-spectrum activity, fluoroquinolones are commonly used in treatment of infections in humans and other animals. 2 Enrofloxacin is one of the antimicrobials typically used to treat colibacillosis in chickens

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in American Journal of Veterinary Research

susceptible to gyrase inhibitors. 12 Enrofloxacin was approved for use in cats in the United States in 1990 at a dosage of 2.5 mg/kg, PO. a,b Enrofloxacin is also approved in the United States for use in dogs and cattle. Prior to FDA approval, enrofloxacin

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in American Journal of Veterinary Research

ciprofloxacin. Enrofloxacin, its active metabolite ciprofloxacin, and marbofloxacin, which are all approved in animals, accumulate in WBCs. 4,5,8,10,11 In dogs, increased concentrations reportedly occur in alveolar macrophages (enrofloxacin, 10-fold

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in American Journal of Veterinary Research

been administered to horses via RILP, including cefotaxime, ampicillin, and vancomycin. 8 However, further investigations are essential to understand the pharmacokinetics of other antimicrobial agents as alternatives for RILP treatments. Enrofloxacin

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in American Journal of Veterinary Research