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H ealth care has improved as the world’s population ages, but the incidence of chronic, progressive neurodegenerative disease has increased. A critical challenge to dementia drug development has been the absence of translational models to drive
characterized by memory loss and cognitive decline. It is the most common form of dementia and a leading cause of death in people over the age of 65, affecting as many as half of those aged 85 or older. 2 In the US alone, the estimated costs for AD treatment
represented a recurrence of lymphoma in this cat. The cat did well clinically until it was brought to the referring veterinarian with acute onset of neurologic signs (dementia, circling, and absent menace reflex) 15 days after the last radiation treatment. The
institutionalized elder with dementia . Geriatr Nurs 2001 ; 22 : 71 – 79 . 10.1067/mgn.2001.115199 14 Hsu Y Serpell JA . Development and validation of a questionnaire for measuring behavior and temperament traits in pet dogs . J Am Vet Med Assoc 2003
animal model of human aging and dementia . Neurobiol Aging 1996 ; 17 : 259 – 268 . 10.1016/0197-4580(95)02060-8 2. Milgram NW , Head E , Weiner E , Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks
Apr 29, 2016 . Available at: www.birminghammail.co.uk/news/midlands-news/married-couple-formed-suicide-pact-11263100 . Accessed Jul 8, 2016. 15. Elderly woman charged in attempted murder-suicide of husband with dementia, pets . Global News Nov
cognitive dysfunction syndrome (comparable to dementia and Alzheimer disease in humans). Cognitive dysfunction is associated with more severe physical and physiologic changes in the brain and may manifest clinically as disorientation; altered social
, cortical atrophy, and sulcal widening as observed with MR. 18–24 In neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia, these changes are more pronounced, occur at faster rates, and can vary regionally. 25,26 In dogs
deficits are more rarely reported, and associated signs have included seizures, obtundation, dementia, behavioral changes, blindness, paresis, ataxia, opisthotonos, and circling. 3,8,11–13 With respect to the present case, it is of particular interest that
