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veterinary graduate of the University College Dublin in Ireland, Dr. Freeman is a professor of equine studies at the University of Florida College of Veterinary Medicine and director of the veterinary college’s Island Whirl Equine Colic Research Laboratory
hay during baling. In a study of 70 horses with cantharidin toxicosis ( J Am Vet Med Assoc 1997;211:1018–1021), most had colic and shock, 10 had polyuria or stranguria, five had diarrhea, two had gastric reflux, two had “thumps” from electrolyte
of the driving gas is a fundamental obstacle to accurate V T delivery by bellows ventilators. This is particularly true for small V T deliveries and high inspiratory pressures, the latter of which often occur in horses undergoing colic surgery in
cholera toxin. 20,37 , r Results of other research have indicated that DTOS prevents the development of diarrhea and improves survival in adult horses with colic s or colitis. 18 Hassel et al s determined that horses with large colon disease that were
Equine gastric ulcer syndrome is a common cause of colic, weight loss, and poor performance in racehorses. 1–3 Ulcers develop primarily in the nonglandular portion of the gastric mucosa, 4,5 and previous studies 6–8 have shown that in the
Abstract
Objectives
To measure coagulation factor VIII:coagulant (F.VIII:C) and C1-esterase inhibitor (C1-INH), hemostasis-associated acute-phase reactant proteins, and coagulation factors VII (F.VII), IX (F.IX), and X (F.X), hemostasis proteins not associated with an acute-phase response, in a select population of horses with colic and hemostasis abnormalities, and presumed to have acute-phase changes. To compare these values and other routine hemostasis test results in the horses with colic with values for a population of healthy horses. To correlate the values of known equine acute-phase reactants, F.VIII:C and fibrinogen, to those of other tests of hemostasis. To identify hemostasis-associated acute-phase reactant proteins and gain insights into the effects the acute-phase response has on hemostatic abnormalities in horses with colic syndrome.
Sample Population
54 plasma samples from horses with colic attributable to inflammatory (n = 39) or strangulating (n = 15) intestinal disorders.
Procedure
Plasma samples were evaluated for activities of F.VII, F.VIII:C, F.IX, F.X, C1-INH, antithrombin III, protein C, plasminogen, and α2-antiplasmin (α2AP); fibrinogen concentration; and prothrombin (PT) and activated partial thromboplastin (APTT) times.
Results
Horses with colic had significantly higher fibrinogen concentration, greater α2AP and protein C activities, and longer PT and APTT than did healthy horses. Horses with colic also had significantly lower mean F.VII activity than did healthy horses. Significant positive correlations between fibrinogen concentration and F.VIII:C, C1-INH, and α2AP values, and between F.VIII:C activity and fibrinogen, C1-INH, α2AP, and plasminogen values were identified.
Conclusions
An acute-phase response contributes to changes observed in coagulation proteins in horses with colic attributable to inflammatory and strangulating intestinal disorders. The data suggest that plasminogen, α2AP, and C1-INH should be considered equine acute-phase proteins. (Am J Vet Res 1998;59:542–545)
of P ≤ 0.005) different from the value in horses treated with SS or lidocaine alone. Discussion In horses, the mortality rate associated with colic surgery is highest during the first 10 days after surgery. 30 Additionally, the short
resistance . J Vet Intern Med 2015 ; 29 : 487 – 498 . 10.1111/jvim.12562 8. Dallap-Schaer BL Linton JK Aceto H . Perioperative antimicrobial drug use and post-operative complications in 762 surgical equine colic patients . J Vet Intern Med
Salmonella enterica is an important cause of disease in adult horses and foals. Clinical signs of salmonellosis in horses include diarrhea, fever, colic, dehydration, and manifestations of septicemia. 1 Horses with peracute salmonellosis can die
systemic adverse effects were detected in any horse during the study period. Moxifloxacin —Five of 6 horses completed this portion of the study. One horse was withdrawn approximately 8 hours after testing began because of gas colic, likely related to a