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would have been missed by intermittent sampling. Studies with IGMs in adult diabetic cats and dogs, including patients with diabetic ketoacidosis, have shown them to be safe and well tolerated with acceptable clinical accuracy. 13 – 18 The use of IGM
available and have been evaluated for use in dogs and cats. The International Organization for Standardization (ISO) has published criteria to evaluate the analytical and clinical accuracy of PBGMs in people, 10 and various veterinary studies 6 , 9 , 11
: explanation and elaboration . BMJ Open 2016 ; 6 : e012799 . 10.1136/bmjopen-2016-012799 Appendix List of the 24 foods or ingredients evaluated in each of 3 assays for AFR, the clinical accuracy of which was assessed in a study involving 30 dogs
abdomen, but there was variation among the different sites. 24 Similarly, in a small group of diabetic cats, FGMS sensor location did not significantly impact clinical accuracy. 25 However, in humans, IG sensors placed on the abdomen reported differing
chemistry analyzer. A negative bias indicated that the CGMS, ICU machine, or POC glucometer underestimated glucose concentrations compared to the chemistry analyzer. The analytical and clinical accuracy of CGMS was determined by comparing glucose
Abstract
Objective—To evaluate the clinical accuracy of reagent test strips used to estimate BUN concentration in dogs and cats.
Design—Prospective study.
Animals—116 dogs and 58 cats.
Procedure—Blood samples were collected at the time of admission to the hospital. Estimates of BUN concentration obtained with reagent test strips (category 1 [5 to 15 mg/dL], 2 [15 to 26 mg/dL], 3 [30 to 40 mg/dL], or 4 [50 to 80 mg/dL]) were compared with SUN concentrations measured with an automated analyzer. For dogs, category 1 and 2 test strip results were considered a negative result (nonazotemic) and category 3 and 4 test strip results were considered a positive result (azotemic). For cats, category 1, 2, and 3 test strip results were considered a negative result (nonazotemic) and category 4 test strip results were considered a positive result (azotemic).
Results—On the basis of SUN concentration, 40 of the 174 (23%) animals (20 dogs and 20 cats) were classified as azotemic. One dog and 2 cats had falsenegative test strip results, and 1 dog had a false-positive result. Sensitivity and specificity were 95% (20/21) and 99% (94/95), respectively, for dogs and 87% (13/15) and 100% (43/43), respectively, for cats.
Conclusions and Clinical Relevance—Results suggest that reagent test strips are a reliable method for rapidly estimating BUN concentrations in dogs and cats. Because test strip results are only semiquantitative and there remains a potential for misclassification, especially in cats, urea nitrogen concentration should ultimately be verified by means of standard chemistry techniques. (J Am Vet Med Assoc 2005;227:1253–1256)
. 2011 ; 48 ( 7 ): 872 – 880 . 20. Teran CG , Torrez-Llanos J , Teran-Miranda TE , Balderrama C , Shah NS , Villarroel P . Clinical accuracy of a non-contact infrared skin thermometer in paediatric practice. Child Care Health Dev
does not improve the clinical accuracy of anterior chamber fluorophotometry. 11 Investigations 6,15,16 in which fluorophotometry results are calculated as percentage increase in the treated versus the contralateral eye involve use of the following
. Diabetes Care 2000 ; 23 : 1143 – 1148 . 10.2337/diacare.23.8.1143 10. Clarke WL Cox D Gonder-Frederick LA , et al. Evaluating clinical accuracy of systems for self-monitoring of blood glucose . Diabetes Care 1987 ; 10 : 622 – 628 . 10
and promote additional studies to determine clinical accuracy and the cost-benefit ratio of this novel diagnostic procedure. ABBREVIATION ILR Implantable loop recorder a. Reveal Plus 9525, Medtronic Inc, Minneapolis, Minn. b
