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progression, is upregulated in human patients with heart failure and correlated with cardiac fibrosis. 4 – 10 Several cell types secrete galectin-3, including activated macrophages, triggering resting fibroblasts into displaying a matrix-forming phenotype. 4

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in American Journal of Veterinary Research

cardiac fibrosis, the microscopic findings suggestive of chronic hypertension, and the bear's irregular and elevated arterial blood pressure measurements during the initial immobilization event supported the hypothesis of a functional pheochromocytoma as

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in Journal of the American Veterinary Medical Association

chronic action of angiotensin II induces proliferation of vascular smooth muscle cells, hypertrophy of cardiac muscle, and formation of interstitial fibrosis. 6–8 Angiotensin II–induced vascular sclerosis and cardiac fibrosis exacerbate cardiac conditions

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in American Journal of Veterinary Research

complexes are associated with cardiac fibrosis and significant intraventricular systolic dyssynchrony in nonischemic dilated cardiomyopathy patients with a narrow QRS interval . Echocardiography 2011 ; 28 : 62 – 68 . 10.1111/j.1540-8175.2010.01242.x 14

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in Journal of the American Veterinary Medical Association
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pulmonary fibrosis (IPF), hepatic fibrosis, Crohn disease, and cardiac fibrosis has led to investigations of FAP–CAR-T cells to treat these conditions. 29 Recently, FAP–CAR-T cells were shown to improve cardiac function in mice with cardiac fibrosis induced

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in Journal of the American Veterinary Medical Association

11.1, Stata Corp, College Station, Tex. References 1. Díez J. Mechanisms of cardiac fibrosis in hypertension . J Clin Hypertens (Greenwich) 2007 ; 9 : 546 – 550 . 10.1111/j.1524-6175.2007.06626.x 2. Lip GY Felmeden DC Li

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in Journal of the American Veterinary Medical Association

cells for regulation of inflammation and cardiac fibrosis is not entirely understood. Better characterization of the immune regulation associated with cardiac diseases may improve the understanding of cardiac disease progression and may provide potential

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in American Journal of Veterinary Research

discrete areas of cardiac fibrosis and evidence of myocardial arteriosclerosis during histologic evaluation of the hearts from dogs with MMVD. However, these evaluations have, so far, been limited to discrete samples taken from a few locations at necropsy

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in American Journal of Veterinary Research

G Deftereos D , et al. Rat strain-related differences in myocardial adrenergic tone and the impact on cardiac fibrosis, adrenergic responsiveness and myocardial structure and function . Pharm Res 2007 ; 55 : 287 – 294 . 10.1016/j.phrs.2006

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in American Journal of Veterinary Research

the transforming growth factor-β1 signal, which contributes to valvular degeneration at the initial stage of cardiac fibrosis. 31 However, some studies 28,34 have shown that homocysteine could be a noteworthy biomarker without being an etiologic

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in American Journal of Veterinary Research