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Canine cognitive decline and Alzheimer disease: clinical insights to solve a shared one-health problem

etiology, pathogenesis, and heterogeneity of the ailment in humans. These models are crucial for research studies. 4 There are substantial similarities in clinical features between AD and canine cognitive decline (CCD). These shared features include the

Open access
Article Category:
Research Article
in Journal of the American Veterinary Medical Association
Page(s):
1597–1604
Online Publication Date:
27 Sep 2023
Keywords:
one health; canine cognitive dysfunction; canine cognitive decline; dementia; Alzheimer disease
One-health approach to canine cognitive decline: Dogs Overcoming Geriatric Memory and Aging Initiative for early detection of cognitive decline

have limited utility as platforms for testing interventions’ potential safety and efficacy. Canine cognitive decline (CCD) is a chronic, progressive neurodegenerative condition with behavioral and pathological symptoms resembling aspects of dementia

Open access
Article Category:
Research Article
in American Journal of Veterinary Research
Online Publication Date:
26 Sep 2023
Keywords:
canine cognitive decline; one health; dementia; p-glycoprotein; DOGMA