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of an antimicrobial drug’s effect and has no clinical significance on its own, which is why breakpoints must be applied for susceptibility interpretation. A breakpoint is an MIC threshold based on clinical, microbiological, and pharmacokinetic

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at these dose ranges. The Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing (VAST) subcommittee approved methods and breakpoints for testing the susceptibility of bacterial isolates from dogs to

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in American Journal of Veterinary Research

intended to provide therapeutic options for practitioners. For this, clinically relevant breakpoints are needed to classify the isolated animal pathogens as clinically susceptible, intermediate, or resistant for a given antimicrobial and should be at least

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in American Journal of Veterinary Research

Abstract

Objective—To determine lactate breakpoint of horses and test for effects of training and dietary supplementation with corn oil on that breakpoint.

Animals—7 healthy Arabian horses.

Procedures—Horses received a control diet (n = 4) or a diet supplemented with 10% corn oil (4). A training program, which comprised two 5-week conditioning periods with 1 week of rest, was initiated. Submaximal incremental exercise tests (IET) were conducted before the first and after both conditioning periods. Blood samples for determination of blood lactate and plasma glucose concentrations were collected 1 minute before IET and during the 15 seconds immediately preceding each speed change. Data collected were fit to one- and twoslope broken-line models and an exponential model.

Results—Good fits were obtained by application of the broken-line models (adjusted R 2 > 0.92) to blood lactate concentration versus speed curves. Lactate breakpoints increased 41% after training but were not affected by diet. After training, slope 2 and peak blood lactate concentrations were greater in the corn oil group, compared with controls. Mean blood lactate concentration at the breakpoint was not affected by training or diet. Plasma glucose concentration versus speed curves also fit the broken-line models, and glucose breakpoints preceded lactate breakpoints by approximately 1 m/s in the second and third IET.

Conclusions and Clinical Relevance—Lactate breakpoints can be determined for horses, using blood lactate concentration versus speed curves generated during submaximal IET and may be useful for assessing fitness and monitoring training programs in equine athletes. (Am J Vet Res 2000;61:144–151)

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in American Journal of Veterinary Research

MIC breakpoints and describing antibiogram creation. 8 – 11 While many different sites are commonly cultured and treated with antimicrobials in veterinary clinical practice, most published antibiograms have focused on urinary tract infections and

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in Journal of the American Veterinary Medical Association

suggest possible benefits of using CI over II to meet PK and pharmacodynamic (PD) targets in dogs with septic peritonitis. Antimicrobial susceptibility breakpoints are developed by the Clinical and Laboratory Standards Institute (CLSI). Reference

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in American Journal of Veterinary Research

antibiogram development in human and animal diagnostic laboratories. 2 The CLSI approves breakpoints, which are concentrations of antimicrobial used to categorize bacteria as susceptible, intermediate, or resistant. 3 Breakpoints are established on the basis

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in Journal of the American Veterinary Medical Association

.5 Nasal cavity   MDR a–c,e,f 0.125 ≤ 0.06 ≥ 2 See Table 2 for key. Effect of the EPI PAβN —Inhibition of the efflux pump resulted in a reduction in the MIC to less than the susceptible breakpoint (0.5 mg/L) for isolates with

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in American Journal of Veterinary Research

administration to dogs and to use the resulting pharmacokinetic data and Monte Carlo simulations to determine whether PK-PD targets for susceptible bacteria could be reached according to reported breakpoints (ie, MIC values used to categorize an organism as

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in American Journal of Veterinary Research

clinicians treating fish to become familiar with aquatic bacterial diseases and the susceptibility of those pathogens to various antimicrobial agents. Although, to our knowledge, clinical breakpoints or interpretive criteria (susceptible, intermediate, and

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in American Journal of Veterinary Research