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autoimmunity, fibrosis, senescence, and infectious disease, suggesting the path to effective treatment of these disease processes using genetically engineered T cells may be less fraught. However, challenges, especially related to the safety of CAR-T cells

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in Journal of the American Veterinary Medical Association

occurs in autoimmune diseases. 40 Therefore, such findings provide the opportunity to search for potential gene polymorphisms between diseased and nondiseased dogs, which may explain potential genetic susceptibilities, if indeed autoimmunity or augmented

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in American Journal of Veterinary Research

IOP, and other forms of cellular stress within the eye and subsequent autoimmunity and retinal and optic nerve damage. In addition to changes related to heat shock proteins, other immunologic deviances have been identified in humans with glaucoma

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in American Journal of Veterinary Research

spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an auto-immune blistering disease affecting mucosae and mucocutaneous junctions . J Autoimmun . 2001 ; 16 : 411 – 421 . 7. Yager JA . Erythema multiforme, Stevens-Johnson syndrome

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in Journal of the American Veterinary Medical Association

. Philadelphia : Elsevier Saunders , 2004 ; 193 – 267 . 2. Papadimitraki ED Bertsias GK Boumpas DT . Toll like receptors and autoimmunity: a critical appraisal . J Autoimmun 2007 ; 29 : 310 – 318 . 10.1016/j.jaut.2007.09.001 3. Foell D

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in American Journal of Veterinary Research

the literature . Oxid Med Cell Longev 2017 ; 2017 : 7265238 . 21. Eisenberg VH Zolti M Soriano D . Is there an association between autoimmunity and endometriosis? Autoimmun Rev 2012 ; 11 : 806 – 814 . 10.1016/j.autrev.2012.01.005 22

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in Journal of the American Veterinary Medical Association

clinical spectrum and treatment options of macrophage activation syndrome in the pediatric age . Eur Rev Med Pharmacol 2006 ; 10 : 53 – 59 . 7 Larroche C Mouthon L . Pathogenesis of hemophagocytic syndrome (HPS) . Autoimmun Rev 2004 ; 3

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in Journal of the American Veterinary Medical Association

disease is unknown, in part due to the lack of conclusive diagnostic antemortem tests. 1 The etiology is unknown, but autoimmune and infectious causes have been postulated. 1 , 2 A prevailing theory is that autoimmunity against myelin P2 causes the

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in Journal of the American Veterinary Medical Association

diagnosis . 2nd ed. Ames, Iowa : Blackwell Publishing , 2005 ; 49 – 74 . 4. Gualtierotti R , Biggioggero M , Penatti MA . at el. Updating on the pathogenesis of systemic lupus erythematosus . Autoimmun Rev 2010 ; 10 : 3 – 7 . 10.1016/j

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in Journal of the American Veterinary Medical Association