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I schemia-reperfusion (I/R) injury, myocardial infarction, creatine kinase release, lactate dehydrogenase (LDH) release, mitochondrial DNA depletion, and apoptosis can occur as consequences of organ dysfunction, due to impaired circulation and

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in American Journal of Veterinary Research

even colonic rupture. 3 In a previous ex vivo study, PBZ and indomethacin were shown to inhibit anion transport, presumably both Cl - and HCO 3 − , and caused apoptosis in the RDC. 6 A more recent study by the authors has demonstrated that the

Open access
in American Journal of Veterinary Research

, adhere to the endothelium, and migrate into the intestinal mucosa, muscle, and serosa. 14–17 Neutrophil apoptosis is one of the principal mechanisms that maintain neutrophil homeostasis. Neutrophils have the ability to release clinically relevant

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in American Journal of Veterinary Research

increases the rate of apoptosis. 3 Most studies of canine IBD have revealed increased proportions of T lymphocytes in the small 4,5 and large intestines 6,7 of dogs with IBD, compared with proportions in the same tissues of healthy dogs. Investigators in

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in American Journal of Veterinary Research

-lymphocyte proliferative responses in PL cattle. 7,11 Thus, the development of leukosis is a complex process that involves altered regulation of cell proliferation and apoptosis of the immune cell populations of cattle. The purpose of the study reported here was to

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in American Journal of Veterinary Research

often leads to collateral damage to adjacent cells and tissues. 4 Cells may undergo apoptosis through 2 pathways. The extrinsic pathway involves activation of cell membrane receptors by specific ligands (eg, tumor necrosis factor-α), which is followed

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in American Journal of Veterinary Research

leads to self-perpetuating chronic inflammation. 5,6 In homeostatic conditions, infiltrating cells are disarmed and removed through apoptosis. 7 During apoptosis, caspases contribute to disassembling and packaging cellular components into membrane

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in American Journal of Veterinary Research

decreasing proteoglycan synthesis (eg, aspirin) and inducing apoptosis (eg, phenylbutazone). 1 Conversely, COX-2 selective NSAIDs appear to protect joints against some degenerative processes. 2–4 Dogs with disorders associated with the CCL are generally

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in American Journal of Veterinary Research

–31 The purpose of the study reported here was to evaluate the effects of calcitriol on proinflammatory and anti-inflammatory cytokine production, neutrophil and lymphocyte apoptosis, and neutrophil and monocyte TLR4 expression in naive (unprimed) and

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in American Journal of Veterinary Research

death that can cause tissue damage by oxidation and nitration of lipids, proteins, and DNA. It may also induce apoptosis or necrosis as a result of acute and severe cellular energetic derangements. 9 Formation of nitrotyrosine via nitration of the

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in American Journal of Veterinary Research