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Several recent studies have evaluated antipyretic and analgesia in adult horses. 8 , 9 Mercer et al, looked at the effect of acetaminophen on multiple parameters after administration of lipopolysaccharide (LPS). 8 Their study found the plasma disposition

Open access
in American Journal of Veterinary Research

Abstract

OBJECTIVE

To describe a unique presentation of systemic Listeria monocytogenes infection in a lactating adult Holstein cow.

ANIMAL

3-year-old second-parity female Holstein, 200 days in milk.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES

A 3-year-old Holstein dairy cow was presented for decreased appetite, decreased milk production, and pyrexia. Blood work displayed marked abnormalities in liver-associated parameters. A diagnosis of L monocytogenes cholangiohepatitis was made following liver biopsy, histopathology, and bacterial culture.

TREATMENT AND OUTCOME

The cow was treated with systemic antimicrobial and antipyretic therapy. The cow was discharged to continue treatment on farm, and at time of last communication with the owner, the cow was doing very well, with full resolution of clinical signs.

CLINICAL RELEVANCE

This case report describes a novel presentation of L monocytogenes infection in an adult bovine. L monocytogenes cholangiohepatitis should be considered a rare differential diagnosis in cattle presenting with evidence of pyrexia and liver disease.

Free access
in Journal of the American Veterinary Medical Association

Abstract

Objective

To evaluate a 5-hydroxytryptamine type-2 receptor antagonist, metrenperone (MET), in alleviating respiratory distress associated with experimentally induced Pasteurella haemolytica pneumonia in feedlot calves.

Design

Double-blind controlled clinical trial.

Animals

30 healthy 6- to 8-month-old Hereford-type calves (250 to 450 kg).

Procedure

Initial measurements were made of rectal temperature (RT), arterial blood gas (ABG) tensions, and pulmonary mechanics. Calves were then infected with P haemolytica in logarithmic phase of growth by intratracheal inoculation. 18 hours later, determination of RT and ABG tensions, and pulmonary function testing were repeated and calves were selected for inclusion in the study on the basis of having 2 of the following: respiratory rate > 50 breaths/mm, RT > 40 C, or Pao2 > 20 mm of Hg below the baseline value. MET (0.1 mg/kg of body weight, IM) or an equivalent vehicle dose was then administered. RT, ABG, and pulmonary mechanics measurements were repeated at 0.5, 1, 2, 3, 4, 6, 12, and 24 hours after treatment. Calves were then euthanatized, and gross necropsy scoring and histologic examination were performed on the lungs.

Results

Infection with P haemolytica caused significant increases in RT and respiratory rate, and reduction in Pao2 , Paco2 , and tidal volume 18 hours after inoculation. MET-treated calves had significantly reduced rectal temperature between 1 and 12 hours, compared with vehicle-treated calves. In addition, MET-treated calves had reduced respiratory rate with concomitantly increased tidal volume between 0.5 and 2 hours after treatment, compared with vehicle-treated calves. Necropsy revealed acute lobar bronchopneumonia in all 30 calves, but there was no difference in necropsy score between treatment groups.

Conclusions and Clinical Relevance

MET may have an antipyretic effect on calves with pneumonia caused by P haemolytica. Its influence on pulmonary mechanics was minimal however, and it did not induce lung lesions in the short term. (Am J Vet Res 1996;57:1034–1039)

Free access
in American Journal of Veterinary Research

Dipyrone is a nonopioid, atypical NSAID that has been available for human use for > 70 years and has been used as an antipyretic and analgesic. The mechanism of action of the antipyretic effects has not been fully clarified; however, evidence

Full access
in American Journal of Veterinary Research

challenge in cats, has significant antipyretic effects, with lower doses of meloxicam resulting in a decreased effect. In that study, a dose of 0.1 mg/kg did not result in as large an antipyretic response as the 0.3 or 0.5 mg/kg dose in cats. The febrile

Full access
in American Journal of Veterinary Research

–1990) . Prog Vet Comp Ophthalmol 1991 ; 1 : 276 – 282 . 13. Chandrasekharan NV , Dai H , Roos KL , et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic / antipyretic drugs: cloning, structure and expression

Full access
in Journal of the American Veterinary Medical Association

pathways and has anti-inflammatory, analgesic, and antipyretic activities. At clinically effective doses, carprofen is a poor inhibitor of prostaglandin synthetase but does prevent CNS sensitization in response to a surgical stimulus when administered

Full access
in Journal of the American Veterinary Medical Association

Dipyrone (metamizole), a potent nonopiate analgesic and antipyretic agent with an additional spasmolytic effect, is widely used in humans to provide perioperative pain relief, whether administered alone or in combination with opioids. 1 In other

Full access
in American Journal of Veterinary Research

drug classes. Robenacoxib is a novel highly selective inhibitor of COX-2. 16 In rats, robenacoxib exerts the analgesic, anti-inflammatory, and antipyretic actions characteristic of NSAIDs, while possessing a much wider safety margin for

Full access
in American Journal of Veterinary Research

centrally. 3–7 The NSAIDS act by inhibiting COX enzymes, which results in reduced biosynthesis of various prostaglandins and antipyretic, anti-inflammatory, and analgesic effects. 6 The COX-1-sparing NSAIDs such as meloxicam exert their effects by

Full access
in American Journal of Veterinary Research