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T he angiopoietin/Tie (Ang/Tie) ligand-receptor system plays a key role in regulating vascular integrity. 1 , 2 Tie-2, a tyrosine kinase receptor expressed in endothelial and hematopoietic stem cells, 2 , 3 is the major receptor in the Ang

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in American Journal of Veterinary Research

Endothelial cell activation and dysfunction are key events in sepsis, leading to leukocyte adhesion, altered vasomotor tone, and increased vascular permeability. 1 The endothelial-specific angiopoietin-Tie ligand receptor system is an important

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in American Journal of Veterinary Research

): 1496 – 1505 . 10.1038/s41590-020-00813-0 30. Kumar H , Choi H , Jo M-J , Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury . Acta Neuropathol Commun . 2018 ; 6 ( 1

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in American Journal of Veterinary Research

proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling . J Biochem (Tokyo) 2008 ; 143 : 199 – 206 . 10.1093/jb/mvm215 31. Sciadini MF Johnson KD . Evaluation of recombinant human bone

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in Journal of the American Veterinary Medical Association