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serum amyloid A (SAA) and alpha-1-acid glycoprotein (AGP). 10 SAA levels increase within 8 hours after inflammatory stimulation and peak at 24 to 48 hours, often rising 10- to 50-fold. 11 SAA, a cytokine-like protein, is recognized for its role in cell

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in American Journal of Veterinary Research

Summary

Changes in serum alpha1-acid glycoprotein (α1 AG) concentration in cattle with hepatic abscesses were observed, and function of α1 ag was evaluated, particularly its influence on cellular immune response. Test cattle (n = 4) were inoculated with Fusobacterium necrophorum, control cattle (n = 2) were inoculated with inactivated bacteria, and naturally affected cattle (n = 11) were found in a slaughterhouse.

Determination of α1 ag was made by use of a single radial immunodiffusion method. The action on lymphocyte blastogenesis was determined by [3H]thymidine incorporation. Cultured lymphocytes from healthy cattle were treated with variable concentrations of α1 ag purified from serum obtained from cattle with hepatic abscesses and suppression of blastogenesis stimulated by each of 3 mitogens was measured.

In cattle with experimentally induced abscesses, serum α1 ag concentration increased for 7 to 10 days after F necrophorum inoculation, its change being parallel to that of sialic acid. High concentration of α1 ag was found in naturally affected cattle and was highly correlated to sialic acid concentration. Suppression of lymphocyte blastogenesis in cattle with experimentally induced hepatic abscesses was highly correlated to serum α1 ag concentration.

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in American Journal of Veterinary Research

inflammation in dogs and cats: the acute phase proteins . Vet Res Commun 2007 ; 31 : 125 – 129 . 10.1007/s11259-007-0107-3 8. Kajikawa T Furuta A Onishi T , et al. Changes in concentrations of serum amyloid A protein, alpha-1-acid glycoprotein

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in American Journal of Veterinary Research

proteins in dogs and cats: current knowledge and future perspectives . Vet Clin Pathol 2005 ; 34 : 85 – 99 . 10.1111/j.1939-165X.2005.tb00019.x 21. Duthie S Eckersall PD Addie DD , et al. Value of alpha 1-acid glycoprotein in the diagnosis

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in American Journal of Veterinary Research

-specific fibronectin 1 transcript variant 262,420 Alpha-2-HS-glycoprotein 38,418 Alpha-fetoprotein 67,861 Alpha-1-acid glycoprotein 21,440 Alpha-1-antiproteinase 46,103 Apolipoprotein A-I preproprotein 30,276 Complement C3 187

Open access
in American Journal of Veterinary Research

Sci 1997 ; 59 : 957 – 960 . 10.1292/jvms.59.957 20. Hahn KA Freeman KP Barnhill MA , Serum alpha 1-acid glycoprotein concentrations before and after relapse in dogs with lymphoma treated with doxorubicin . J Am Vet Med Assoc 1999 ; 214

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in Journal of the American Veterinary Medical Association

0034-5288(18)30902-0 22. Rikihisa Y Yamamoto S Kwak I , et al. C-reactive protein and alpha 1-acid glycoprotein levels in dogs infected with Ehrlichia canis . J Clin Microbiol 1994 ; 32 : 912 – 917 . 10.1128/jcm.32.4.912-917.1994 23

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in Journal of the American Veterinary Medical Association

: 1201 – 1210 . 10.2460/javma.239.9.1201 13. Rikihisa Y , Yamamoto S , Kwak I. C-reactive protein and alpha-1-acid glycoprotein levels in dogs infected with Ehrlichia canis . J Clin Microbiol 1994 ; 32 : 912 – 917 . 10.1128/jcm.32

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in American Journal of Veterinary Research

; 39 : 460 – 468 . 10.1111/jvp.12302 41. Bista SR Haywood A Hardy J , et al. Protein binding of fentanyl and its metabolite nor-fentanyl in human plasma, albumin and alpha-1 acid glycoprotein . Xenobiotica 2015 ; 45 : 207 – 212 . 10

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in American Journal of Veterinary Research

; 352 : 1611 – 1613 . 10.1056/NEJM200504143521525 53. Hayashi S Jinbo T Iguchi K , et al. A comparison of the concentrations of C-reactive protein and alpha1-acid glycoprotein in the serum of young and adult dogs with acute inflammation . Vet

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in Journal of the American Veterinary Medical Association