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from those mortality rates, we estimate that 6.2 to 6.8 million pet dogs died in the US in 2020. In a study 4 in the UK, it was found that of dogs that died, 86% were euthanized. An initial report from the Dog Aging Project (DAP) 5 found a euthanasia
Dog Aging Project (DAP) is a revolutionary cohort of over 45,000 dogs located across the US, 1 with longitudinal data collected annually from dog owners through a series of survey instruments. This cohort provides the unique opportunity to study dog
Introduction A common goal among aging studies is elucidating the causes and consequences of aging in order to improve life span and/or health span, the period of one’s life span spent free from chronic or debilitating conditions. As such, the
life appropriate to different stages of aging. At a minimum, knowing the average life expectancy for a given species enables us to estimate when different life stages might start and end. Such knowledge can also help inform when we might expect certain
A significant decrease in hepatic drug metabolism or renal function with advancing age could markedly reduce the drug elimination in aged animals and thus increase the risk of drug toxicity. For example, the elimination half-life of drugs
. Outcome Survival was considered as being successfully discharged from hospital. Statistical analysis Variables assessed included age, rectal temperature, and clinicopathologic findings on presentation, specifically BUN, plasma glucose, sodium
Although it is often misconstrued as such, aging is not a pathological process but rather comprises the normal, time-dependent changes that occur during the later stages of life in every animal. Today, it is generally accepted that healthy aging
In the broadest sense, aging refers to the natural, progressive series of life stages beginning with conception and continuing through development, maturation, and senescence. Most often, however, the term is more narrowly used to refer to the
The concept of frailty was introduced in 1968 and has become a major aspect of the study of biological aging. Frailty is a biological syndrome characterized by a decrease in the physiological reserves 1 and an increase in vulnerability to
What Is Aging? For a phenomenon we all experience, aging is challenging to define precisely. It involves changes that occur over time, but time is not necessarily the primary driver of those changes. Aging can be understood from the
